1YC2
Sir2Af2-NAD-ADPribose-nicotinamide
Summary for 1YC2
Entry DOI | 10.2210/pdb1yc2/pdb |
Descriptor | NAD-dependent deacetylase 2, ADENOSINE-5-DIPHOSPHORIBOSE, ZINC ION, ... (11 entities in total) |
Functional Keywords | sir2, sirtuin, nicotinamide, nad, adpribose, ternary complex, hydrolase |
Biological source | Archaeoglobus fulgidus |
Cellular location | Cytoplasm (Probable): O30124 |
Total number of polymer chains | 5 |
Total formula weight | 149541.70 |
Authors | Avalos, J.L.,Bever, M.K.,Wolberger, C. (deposition date: 2004-12-21, release date: 2005-03-29, Last modification date: 2024-02-14) |
Primary citation | Avalos, J.L.,Bever, K.M.,Wolberger, C. Mechanism of Sirtuin Inhibition by Nicotinamide: Altering the NAD(+) Cosubstrate Specificity of a Sir2 Enzyme. Mol.Cell, 17:855-868, 2005 Cited by PubMed: 15780941DOI: 10.1016/j.molcel.2005.02.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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