Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1YC2

Sir2Af2-NAD-ADPribose-nicotinamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006338	biological_process	chromatin remodeling
A	0006351	biological_process	DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0016740	molecular_function	transferase activity
A	0017136	molecular_function	histone deacetylase activity, NAD-dependent
A	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
A	0036054	molecular_function	protein-malonyllysine demalonylase activity
A	0036055	molecular_function	protein-succinyllysine desuccinylase activity
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding
B	0005737	cellular_component	cytoplasm
B	0006338	biological_process	chromatin remodeling
B	0006351	biological_process	DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0016740	molecular_function	transferase activity
B	0017136	molecular_function	histone deacetylase activity, NAD-dependent
B	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
B	0036054	molecular_function	protein-malonyllysine demalonylase activity
B	0036055	molecular_function	protein-succinyllysine desuccinylase activity
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
B	0070403	molecular_function	NAD+ binding
C	0005737	cellular_component	cytoplasm
C	0006338	biological_process	chromatin remodeling
C	0006351	biological_process	DNA-templated transcription
C	0008270	molecular_function	zinc ion binding
C	0016740	molecular_function	transferase activity
C	0017136	molecular_function	histone deacetylase activity, NAD-dependent
C	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
C	0036054	molecular_function	protein-malonyllysine demalonylase activity
C	0036055	molecular_function	protein-succinyllysine desuccinylase activity
C	0046872	molecular_function	metal ion binding
C	0051287	molecular_function	NAD binding
C	0070403	molecular_function	NAD+ binding
D	0005737	cellular_component	cytoplasm
D	0006338	biological_process	chromatin remodeling
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0016740	molecular_function	transferase activity
D	0017136	molecular_function	histone deacetylase activity, NAD-dependent
D	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
D	0036054	molecular_function	protein-malonyllysine demalonylase activity
D	0036055	molecular_function	protein-succinyllysine desuccinylase activity
D	0046872	molecular_function	metal ion binding
D	0051287	molecular_function	NAD binding
D	0070403	molecular_function	NAD+ binding
E	0005737	cellular_component	cytoplasm
E	0006338	biological_process	chromatin remodeling
E	0006351	biological_process	DNA-templated transcription
E	0008270	molecular_function	zinc ion binding
E	0016740	molecular_function	transferase activity
E	0017136	molecular_function	histone deacetylase activity, NAD-dependent
E	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
E	0036054	molecular_function	protein-malonyllysine demalonylase activity
E	0036055	molecular_function	protein-succinyllysine desuccinylase activity
E	0046872	molecular_function	metal ion binding
E	0051287	molecular_function	NAD binding
E	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	CYS126
A	CYS129
A	CYS150
A	CYS153

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 402

Chain	Residue
A	HIS17
A	GLU180
A	HIS183
C	HIS130

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 403

Chain	Residue
B	CYS129
B	CYS150
B	CYS153
B	CYS126

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 404

Chain	Residue
B	HIS17
B	GLU180
B	HIS183
D	HIS130

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 405

Chain	Residue
C	CYS126
C	CYS129
C	CYS150
C	CYS153

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 406

Chain	Residue
A	HIS130
C	HIS17
C	GLU180
C	HIS183

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 407

Chain	Residue
D	CYS126
D	CYS129
D	CYS150
D	CYS153

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 408

Chain	Residue
B	HIS130
D	HIS17
D	GLU180
D	HIS183

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 409

Chain	Residue
E	CYS126
E	CYS129
E	CYS150
E	CYS153

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 601

Chain	Residue
A	PRO170
A	GLN171
A	ARG172
C	PRO170
C	GLN171
C	ARG172
C	THR173

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 602

Chain	Residue
B	PRO170
B	GLN171
B	ARG172
B	THR173
B	HOH719
D	PRO170
D	GLN171
D	ARG172

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 603

Chain	Residue
D	ARG161

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 604

Chain	Residue
B	LYS123
B	THR132
B	ARG161

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 605

Chain	Residue
A	LYS123
A	ARG161

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 606

Chain	Residue
C	LYS123
C	THR132
C	ARG161

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 607

Chain	Residue
A	MET91
A	LYS247
D	ARG90

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 609

Chain	Residue
B	ARG6
B	LYS7
E	ARG112

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 610

Chain	Residue
B	ARG149

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 612

Chain	Residue
A	LYS57
B	LYS208
C	LYS182

site_id	CC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD B 501

Chain	Residue
B	GLY23
B	ALA24
B	GLY25
B	ALA28
B	GLU29
B	ILE32
B	THR34
B	PHE35
B	ARG36
B	GLN100
B	ASN101
B	ILE102
B	ASP103
B	HIS118
B	GLY191
B	SER193
B	ASN217
B	ALA218
B	GLU219
B	GLY233
B	LYS234
B	ALA235
B	2PE701
B	HOH713
B	HOH744
B	HOH752
B	HOH770

site_id	CC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD C 502

Chain	Residue
C	GLY25
C	ALA28
C	GLU29
C	THR34
C	PHE35
C	ARG36
C	GLN100
C	ASN101
C	ILE102
C	ASP103
C	HIS118
C	GLY191
C	SER193
C	ASN217
C	ALA218
C	GLU219
C	LYS234
C	ALA235
C	2PE702
C	HOH703
C	HOH706
C	HOH733
C	GLY23
C	ALA24

site_id	CC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NAD A 503

Chain	Residue
A	GLY23
A	ALA24
A	GLY25
A	GLU29
A	THR34
A	PHE35
A	ARG36
A	GLU38
A	GLN100
A	GLY191
A	SER192
A	SER193
A	ASN217
A	ALA218
A	GLU219
A	GLY233
A	LYS234
A	ALA235
A	HOH715
A	HOH748

site_id	CC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE APR E 504

Chain	Residue
E	GLY23
E	ALA24
E	GLY25
E	ALA28
E	GLU29
E	THR34
E	PHE35
E	ARG36
E	TRP42
E	GLN100
E	HIS118
E	PHE165
E	GLY191
E	SER192
E	SER193
E	ASN217
E	ALA218
E	GLU219
E	GLY233
E	LYS234
E	ALA235
E	HOH521

site_id	CC6
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD D 505

Chain	Residue
C	HOH726
C	HOH737
D	GLY23
D	ALA24
D	GLY25
D	ALA28
D	GLU29
D	THR34
D	PHE35
D	ARG36
D	GLU38
D	GLN100
D	GLY191
D	SER192
D	SER193
D	VAL195
D	VAL196
D	ASN217
D	ALA218
D	GLU219
D	GLY233
D	LYS234
D	ALA235
D	PG4703
D	HOH733

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NCA A 506

Chain	Residue
A	PRO33
A	PHE35
A	ASN101
A	ILE102
A	ASP103
A	EDO704

site_id	CC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NCA E 507

Chain	Residue
E	ILE32
E	PRO33
E	PHE35
E	LEU41
E	ASN101
E	ILE102
E	ASP103

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NCA B 508

Chain	Residue
B	GLN171
C	TYR197

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NCA E 509

Chain	Residue
A	LYS208
A	ALA209
E	GLU131
E	TYR133
E	ARG151
E	LYS152

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NCA D 510

Chain	Residue
D	PRO33
D	PHE35
D	ASN101
D	ILE102
D	ASP103

site_id	DC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 2PE B 701

Chain	Residue
B	PHE66
B	SER67
B	MET70
B	ILE102
B	ASP103
B	HIS118
B	MET121
B	PHE165
B	VAL196
B	TYR197
B	NAD501
B	HOH761

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 2PE C 702

Chain	Residue
C	SER67
C	ILE102
C	HIS118
C	VAL163
C	TYR197
C	NAD502

site_id	DC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PG4 D 703

Chain	Residue
D	PHE35
D	SER67
D	HIS118
D	VAL163
D	PHE165
D	NAD505

site_id	DC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 704

Chain	Residue
A	NCA506

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 706

Chain	Residue
A	SER67
A	MET121

site_id	DC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 707

Chain	Residue
B	ARG61

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 708

Chain	Residue
B	LYS159
B	VAL162
B	GLU167
D	ARG172
D	HOH710

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE D 709

Chain	Residue
D	LYS71
D	ASP72
D	TRP135

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	753
Details	Domain: {"description":"Deacetylase sirtuin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	5
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	155
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01121","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15023335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15780941","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)