1YC5
Sir2-p53 peptide-nicotinamide
Summary for 1YC5
Entry DOI | 10.2210/pdb1yc5/pdb |
Related | 1YC2 |
Descriptor | NAD-dependent deacetylase, Cellular tumor antigen p53 peptide, ZINC ION, ... (5 entities in total) |
Functional Keywords | sir2, sirtuin, sir2tm, sirt1, p53, nicotinamide, hydrolase |
Biological source | Thermotoga maritima More |
Cellular location | Cytoplasm (Probable): Q9WYW0 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: Q9NP68 |
Total number of polymer chains | 2 |
Total formula weight | 29896.85 |
Authors | Avalos, J.L.,Bever, M.K.,Wolberger, C. (deposition date: 2004-12-21, release date: 2005-04-26, Last modification date: 2011-07-13) |
Primary citation | Avalos, J.L.,Bever, K.M.,Wolberger, C. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol.Cell, 17:855-868, 2005 Cited by PubMed: 15780941DOI: 10.1016/j.molcel.2005.02.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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