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4IJD
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BU of 4ijd by Molmil
Crystal structure of methyltransferase domain of human PR domain-containing protein 9
Descriptor: Histone-lysine N-methyltransferase PRDM9, UNKNOWN ATOM OR ION, ZINC ION
Authors:Dong, A, Dombrovski, L, Li, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2012-12-21
Release date:2013-02-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of methyltransferase domain of human PR domain-containing protein 9
To be Published
4JXM
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BU of 4jxm by Molmil
Crystal structure of RRP9 WD40 repeats
Descriptor: U3 small nucleolar RNA-interacting protein 2, UNKNOWN ATOM OR ION
Authors:Wu, X, Tempel, W, Xu, C, El Bakkouri, M, He, H, Seitova, A, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-03-28
Release date:2013-04-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of RRP9 WD40 repeats
To be Published
7U9I
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BU of 7u9i by Molmil
Co-crystal structure of human CARM1 in complex with MT556 inhibitor
Descriptor: 7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Histone-arginine methyltransferase CARM1, UNKNOWN ATOM OR ION
Authors:Zeng, H, Perveen, S, Dong, A, Hutchinson, A, Seitova, A, Gibson, E, Hajian, T, Li, Y, Gao, Y.D, Schneider, S, Siliphaivanh, P, Sloman, D, Nicholson, B, Fischer, C, Hicks, J, Vedadi, M, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2022-03-10
Release date:2023-01-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Co-crystal structure of human CARM1 in complex with MT556 inhibitor
To Be Published
7UNK
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BU of 7unk by Molmil
Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex
Descriptor: Histone H3, Histone H4, Histone chaperone, ...
Authors:Bernardes, N.E, Chook, Y.M, Fung, H.Y.J, Chen, Z, Li, Y.
Deposit date:2022-04-11
Release date:2022-09-21
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.
Proc.Natl.Acad.Sci.USA, 119, 2022
5FAI
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BU of 5fai by Molmil
EMG1 N1-Specific Pseudouridine Methyltransferase
Descriptor: CITRIC ACID, Ribosomal RNA small subunit methyltransferase NEP1, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:DONG, A, ZENG, H, LI, Y, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:2015-12-11
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:EMG1 N1-Specific Pseudouridine Methyltransferase
to be published
8WA3
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BU of 8wa3 by Molmil
Cryo-EM structure of peptide free and Gs-coupled GIPR
Descriptor: Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ...
Authors:Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W.
Deposit date:2023-09-06
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
8WG8
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BU of 8wg8 by Molmil
Cryo-EM structures of peptide free and Gs-coupled GCGR
Descriptor: Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W.
Deposit date:2023-09-20
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (2.71 Å)
Cite:Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
8WG7
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BU of 8wg7 by Molmil
Cryo-EM structures of peptide free and Gs-coupled GLP-1R
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W.
Deposit date:2023-09-20
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
4K12
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BU of 4k12 by Molmil
Structural Basis for Host Specificity of Factor H Binding by Streptococcus pneumoniae
Descriptor: Choline binding protein A, Complement factor H
Authors:Liu, A, Achila, D, Banerjee, R, Martinez-Hackert, E, Li, Y, Yan, H.
Deposit date:2013-04-04
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.079 Å)
Cite:Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae.
Biochem.J., 465, 2015
4KY1
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BU of 4ky1 by Molmil
humanized HP1/2 Fab
Descriptor: IMMUNOGLOBULIN IGG1 FAB, HEAVY CHAIN, LIGHT CHAIN
Authors:Arndt, J.W, Hanf, K.J.M, Lugovskoy, A, Chen, L.L, Jarpe, M, Boriack-Sjodin, A, Li, Y, van Vlijmen, H, Pepinsky, B, Taylor, F, Silvian, L, Taveras, A.
Deposit date:2013-05-28
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework.
METHODS (SAN DIEGO), 65, 2014
5FRS
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BU of 5frs by Molmil
Structure of the Pds5-Scc1 complex and implications for cohesin function
Descriptor: SISTER CHROMATID COHESION PROTEIN 1, SISTER CHROMATID COHESION PROTEIN PDS5
Authors:Muir, K.W, Kschonsak, M, Li, Y, Metz, J, Haering, C.H, Panne, D.
Deposit date:2015-12-22
Release date:2016-03-02
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (4.073 Å)
Cite:Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function
Cell Rep., 14, 2016
5FRP
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BU of 5frp by Molmil
Structure of the Pds5-Scc1 complex and implications for cohesin function
Descriptor: MCD1-LIKE PROTEIN, SISTER CHROMATID COHESION PROTEIN PDS5
Authors:Muir, K.W, Kschonsak, M, Li, Y, Metz, J, Haering, C.H, Panne, D.
Deposit date:2015-12-21
Release date:2016-03-02
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.895 Å)
Cite:Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function
Cell Rep., 14, 2016
5GJ4
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BU of 5gj4 by Molmil
Structure of NS2B-NS3 Protease from Zika Virus caught after self-cleavage
Descriptor: CHLORIDE ION, Serine protease NS3, Serine protease subunit NS2B
Authors:Phoo, W.W, Li, Y.
Deposit date:2016-06-27
Release date:2016-10-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.839 Å)
Cite:Structure of the NS2B-NS3 protease from Zika virus after self-cleavage.
Nat Commun, 7, 2016
5H43
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BU of 5h43 by Molmil
Structural and mechanistical studies of the nuclear import by Importin-alpha
Descriptor: Histone acetyltransferase KAT8, Importin subunit alpha-1
Authors:Wang, R, Li, Y.
Deposit date:2016-10-28
Release date:2017-10-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin alpha 1
Traffic, 19, 2018
4J4Q
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BU of 4j4q by Molmil
Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside
Descriptor: ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ...
Authors:Park, J.H, Morizumi, T, Li, Y, Hong, J.E, Pai, E.F, Hofmann, K.P, Choe, H.W, Ernst, O.P.
Deposit date:2013-02-07
Release date:2013-10-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Opsin, a structural model for olfactory receptors?
Angew.Chem.Int.Ed.Engl., 52, 2013
5W1Y
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BU of 5w1y by Molmil
SETD8 in complex with a covalent inhibitor
Descriptor: 2-(4-methylpiperazin-1-yl)-3-(phenylsulfanyl)naphthalene-1,4-dione, N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION
Authors:Tempel, W, Yu, W, Li, Y, Blum, G, Luo, M, Pittella-Silva, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2017-06-05
Release date:2017-06-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:SETD8 in complex with a covalent inhibitor
to be published
5VLQ
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BU of 5vlq by Molmil
Structure of the TTLL3 Glycylase
Descriptor: LOC100158544 protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION
Authors:Garnham, C.P, Yu, I, Li, Y, Roll-Mecak, A.
Deposit date:2017-04-25
Release date:2017-05-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.285 Å)
Cite:Crystal structure of tubulin tyrosine ligase-like 3 reveals essential architectural elements unique to tubulin monoglycylases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8VIS
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BU of 8vis by Molmil
Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ...
Authors:Fraser, B.J, Dong, A, Ilyassov, O, Kenney, T, Li, Y.Y, Seitova, A, Li, Y, Hejazi, Z, Edwards, A, Benard, F, Arrowsmith, C.
Deposit date:2024-01-05
Release date:2024-01-31
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide
To Be Published
6LZ2
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BU of 6lz2 by Molmil
Crystal structure of a thermostable green fluorescent protein (TGP) with a synthetic nanobody (Sb44)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GLYCEROL, ...
Authors:Cai, H, Yao, H, Li, T, Hutter, C, Tang, Y, Li, Y, Seeger, M, Li, D.
Deposit date:2020-02-17
Release date:2020-12-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:An improved fluorescent tag and its nanobodies for membrane protein expression, stability assay, and purification.
Commun Biol, 3, 2020
5Y5N
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BU of 5y5n by Molmil
Crystal structure of human Sirtuin 2 in complex with a selective inhibitor
Descriptor: 2-[[3-(2-phenylethoxy)phenyl]amino]benzamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION
Authors:Mellini, P, Itoh, Y, Tsumoto, H, Li, Y, Suzuki, M, Tokuda, N, Kakizawa, T, Miura, Y, Takeuchi, J, Lahtela-Kakkonen, M, Suzuki, T.
Deposit date:2017-08-09
Release date:2017-09-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Potent mechanism-based sirtuin-2-selective inhibition by anin situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site.
Chem Sci, 8, 2017
5X29
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BU of 5x29 by Molmil
NMR structure of the SARS Coronavirus E protein pentameric ion channel
Descriptor: Envelope small membrane protein
Authors:Torres, J, Surya, W, Li, Y.
Deposit date:2017-01-31
Release date:2017-06-07
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural model of the SARS coronavirus E channel in LMPG micelles
Biochim. Biophys. Acta, 1860, 2018
5XI4
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BU of 5xi4 by Molmil
BRD4 bound with compound Bdi4
Descriptor: (3~{S})-4-cyclopropyl-1,3-dimethyl-6-[[(1~{S})-1-(4-methylphenyl)ethyl]amino]-3~{H}-quinoxalin-2-one, Bromodomain-containing protein 4
Authors:Xiong, B, Cao, D, Li, Y.
Deposit date:2017-04-25
Release date:2018-05-02
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.486 Å)
Cite:BRD4 bound with compound Bdi4
To Be Published
5XI3
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BU of 5xi3 by Molmil
BRD4 bound with compound Bdi3
Descriptor: (3~{R})-4-cyclopropyl-1,3-dimethyl-6-[[(1~{R})-1-phenylethyl]amino]-3~{H}-quinoxalin-2-one, Bromodomain-containing protein 4
Authors:Xiong, B, Cao, D, Li, Y.
Deposit date:2017-04-25
Release date:2018-05-02
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.674 Å)
Cite:BRD4 bound with compound Bdi3
To Be Published
8T9A
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BU of 8t9a by Molmil
CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3
Descriptor: DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, Melanoma-associated antigen 3
Authors:Duda, D, Righetto, G, Li, Y, Loppnau, P, Seitova, A, Santhakumar, V, Halabelian, L, Yin, Y.
Deposit date:2023-06-23
Release date:2024-04-10
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3
To Be Published
8Y6P
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BU of 8y6p by Molmil
Structure of the auto-inhibited Dark monomer
Descriptor: Apaf-1 related killer DARK
Authors:Tian, L, Li, Y, Shi, Y.
Deposit date:2024-02-03
Release date:2024-04-10
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Dark and Dronc activation in Drosophila melanogaster.
Proc.Natl.Acad.Sci.USA, 121, 2024

223532

数据于2024-08-07公开中

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