5Y5N
Crystal structure of human Sirtuin 2 in complex with a selective inhibitor
Summary for 5Y5N
Entry DOI | 10.2210/pdb5y5n/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, 2-[[3-(2-phenylethoxy)phenyl]amino]benzamide, ... (4 entities in total) |
Functional Keywords | pseudopeptides, anticancer activity, neurite outgrowth, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38234.19 |
Authors | Mellini, P.,Itoh, Y.,Tsumoto, H.,Li, Y.,Suzuki, M.,Tokuda, N.,Kakizawa, T.,Miura, Y.,Takeuchi, J.,Lahtela-Kakkonen, M.,Suzuki, T. (deposition date: 2017-08-09, release date: 2017-09-06, Last modification date: 2023-11-22) |
Primary citation | Mellini, P.,Itoh, Y.,Tsumoto, H.,Li, Y.,Suzuki, M.,Tokuda, N.,Kakizawa, T.,Miura, Y.,Takeuchi, J.,Lahtela-Kakkonen, M.,Suzuki, T. Potent mechanism-based sirtuin-2-selective inhibition by anin situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site. Chem Sci, 8:6400-6408, 2017 Cited by PubMed: 28989670DOI: 10.1039/c7sc02738a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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