5Y5N
Crystal structure of human Sirtuin 2 in complex with a selective inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacetylase sirtuin-2 | polymer | 336 | 37836.4 | 1 | UniProt (Q8IXJ6) Pfam (PF02146) | Homo sapiens (Human) | Regulatory protein SIR2 homolog 2,SIR2-like protein 2 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 2-[[3-(2-phenylethoxy)phenyl]amino]benzamide | non-polymer | 332.4 | 1 | Chemie (8NO) | |||
| 4 | D (A) | water | water | 18.0 | 102 | Chemie (HOH) |
Sequence modifications
A: 34 - 356 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| Gly 32 | - | see sequence details |
| Ser 33 | - | see sequence details |
| Leu 288 | - | see sequence details |
| Gly 288 | - | see sequence details |
| Glu 288 | - | see sequence details |
| Thr 288 | - | see sequence details |
| Pro 288 | - | see sequence details |
| Phe 288 | - | see sequence details |
| Asp 289 | - | see sequence details |
| Asp 289 | - | see sequence details |
| Ile 289 | - | see sequence details |
| Ala 289 | - | see sequence details |
| Thr 289 | - | see sequence details |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37836.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 397.8 | |
| All* | Total formula weight | 38234.2 |
