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Crystal structure of the A/Michigan/15/2014 (H3N2) influenza virus hemagglutinin in complex with 6'-SLN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-11-09
Release date:	2018-02-28
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun, 9, 2018

4NZT

Crystal structure of the antibody-binding region of Protein M (Protein M TD) in complex with anti-infleunza hemagglutinin antibody CR9114 Fab
Descriptor:	CR9114 heavy chain, CR9114 light chain, Protein M TD
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2013-12-12
Release date:	2014-02-19
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.497 Å)
Cite:	A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union. Science, 343, 2014

4NM8

Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody CR8043, ...
Authors:	Lee, P.S, Wilson, I.A.
Deposit date:	2013-11-14
Release date:	2013-12-25
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (4.0041 Å)
Cite:	A common solution to group 2 influenza virus neutralization. Proc.Natl.Acad.Sci.USA, 111, 2014

4NM4

Crystal structure of broadly neutralizing antibody CR8043
Descriptor:	Antibody CR8043, Heavy Chain, Light Chain, ...
Authors:	Lee, P.S, Wilson, I.A.
Deposit date:	2013-11-14
Release date:	2013-12-25
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	A common solution to group 2 influenza virus neutralization. Proc.Natl.Acad.Sci.USA, 111, 2014

4NUJ

Crystal structure of HIV-1 broadly neutralizing antibody PGT152
Descriptor:	PGT152 heavy chain, PGT152 light chain
Authors:	Blattner, C, Wilson, I.A.
Deposit date:	2013-12-03
Release date:	2014-05-14
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.827 Å)
Cite:	Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers. Immunity, 40, 2014

4NZU

Crystal structure of the primary monoclonal antibody 13PL Fab' from a multiple myeloma patient
Descriptor:	13PL heavy chain, 13PL light chain, ACETATE ION, ...
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2013-12-12
Release date:	2014-02-19
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (1.2 Å)
Cite:	A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union. Science, 343, 2014

6CFG

Crystal structure of the A/Vietnam/1203/2004 (H5N1) influenza virus hemagglutinin in complex with small molecule JNJ4796
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:	Kadam, R.U, Wilson, I.A.
Deposit date:	2018-02-14
Release date:	2019-02-13
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science, 363, 2019

4O58

Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/3/1975 (H3N2) influenza hemagglutinin
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:	Lee, P.S, Wilson, I.A.
Deposit date:	2013-12-19
Release date:	2014-04-16
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.7501 Å)
Cite:	Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus. Nat Commun, 5, 2014

6CF7

Crystal structure of the A/Solomon Islands/3/2006(H1N1) influenza virus hemagglutinin in complex with small molecule JNJ4796
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:	Kadam, R.U, Wilson, I.A.
Deposit date:	2018-02-13
Release date:	2019-02-13
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (2.719 Å)
Cite:	A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science, 363, 2019

6D0U

Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody C05 V110P/A117E mutant, heavy chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2018-04-11
Release date:	2019-01-16
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (3.25 Å)
Cite:	Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses. Proc. Natl. Acad. Sci. U.S.A., 116, 2019

6CXL

anti-HIV-1 Fab 2G12 in complex with glycopeptide 10F5
Descriptor:	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose, anti-HIV-1 Fab 2G12 heavy chain, anti-HIV-1 Fab 2G12 light chain
Authors:	Stanfield, R.L, Wilson, I.A.
Deposit date:	2018-04-03
Release date:	2019-02-20
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (3.586 Å)
Cite:	Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities. ACS Cent Sci, 5, 2019

6D2P

Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A
Descriptor:	GLYCEROL, Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, IOMAclass naive CLK31 Fab heavy chain, ...
Authors:	Sarkar, A, Wilson, I.A.
Deposit date:	2018-04-13
Release date:	2019-01-16
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen. Sci Transl Med, 10, 2018

4NWU

Crystal structure of APE1551, an anti-human NGF Fab with a nine amino acid insertion in CDR H1
Descriptor:	APE1551 Ab Fab heavy chain, APE1551 Ab Fab light chain
Authors:	Verdino, P, Stanfield, R.L, Wilson, I.A.
Deposit date:	2013-12-06
Release date:	2014-10-22
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (1.602 Å)
Cite:	Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies. J.Biol.Chem., 289, 2014

4NZR

Crystal structure of the antibody-binding region of Protein M (Protein M TD) in complex with anti-HIV antibody PGT135 Fab
Descriptor:	GLYCEROL, PGT135 heavy chain, PGT135 light chain, ...
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2013-12-12
Release date:	2014-02-19
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union. Science, 343, 2014

4NGH

Crystal structure of the HIV-1 neutralizing antibody 4E10 Fab fragment in complex with a hydrocarbon-stapled peptide containing the 4e10 epitope on gp41 and a tethered phosphate moiety.
Descriptor:	FAB HEAVY CHAIN, FAB LIGHT CHAIN, MODIFIED FRAGMENT OF HIV GLYCOPROTEIN (GP41)
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2013-11-01
Release date:	2014-12-03
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.68 Å)
Cite:	Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. Nat.Struct.Mol.Biol., 21, 2014

4NJ9

Crystal structure of Fab 8B10 in complex with MPTS
Descriptor:	8-methoxypyrene-1,3,6-trisulfonic acid, 8B10 heavy chain, 8B10 light chain, ...
Authors:	Stanfield, R.L, Romesberg, F.E, Zimmermann, J, Wilson, I.A.
Deposit date:	2013-11-08
Release date:	2014-11-12
Last modified:	2017-06-14
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Adaptive Mutations Alter Antibody Structure and Dynamics during Affinity Maturation. Biochemistry, 54, 2015

6CA9

Crystal structure of Fab PCT64_LMCA (SAR), the least mutated common ancestor of the HIV-1 broadly neutralizing antibody lineage PCT64
Descriptor:	DI(HYDROXYETHYL)ETHER, GLYCEROL, PCT64_LMCA Fab heavy chain, ...
Authors:	Omorodion, O, Wilson, I.A.
Deposit date:	2018-01-29
Release date:	2018-06-27
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.702 Å)
Cite:	Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design. Cell Rep, 23, 2018

4NCO

Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP gp120, BG505 SOSIP gp41, ...
Authors:	Julien, J.-P, Stanfield, R.L, Lyumkis, D, Ward, A.B, Wilson, I.A.
Deposit date:	2013-10-24
Release date:	2013-11-13
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (4.7 Å)
Cite:	Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science, 342, 2013

6CA7

Crystal structure of PCT64_13C, a strain specific anti-HIV antibody
Descriptor:	PCT64_13C heavy chain, PCT64_13C light chain
Authors:	Murrell, S, Wilson, I.A.
Deposit date:	2018-01-29
Release date:	2018-06-27
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (1.643 Å)
Cite:	Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design. Cell Rep, 23, 2018

4NPY

Crystal structure of germline Fab PGT121, a putative precursor of the broadly reactive and potent HIV-1 neutralizing antibody
Descriptor:	GLYCEROL, germline PGT121 heavy chain, germline PGT121 light chain
Authors:	Julien, J.-P, Diwanji, D.C, Wilson, I.A.
Deposit date:	2013-11-22
Release date:	2013-12-11
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (1.796 Å)
Cite:	The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies. Plos Pathog., 9, 2013

6CA6

Crystal structure of PCT64_35S, a broadly neutralizing anti-HIV antibody.
Descriptor:	DI(HYDROXYETHYL)ETHER, GLYCEROL, PCT64_35S heavy chain, ...
Authors:	Murrell, S, Wilson, I.A.
Deposit date:	2018-01-29
Release date:	2018-06-27
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.43 Å)
Cite:	Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design. Cell Rep, 23, 2018

6BKP

Crystal structure of the A/Michigan/15/2014 (H3N2) influenza virus hemagglutinin apo form
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-11-09
Release date:	2018-02-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun, 9, 2018

4O5N

Crystal structure of A/Victoria/361/2011 (H3N2) influenza virus hemagglutinin
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:	Lee, P.S, Wilson, I.A.
Deposit date:	2013-12-19
Release date:	2014-04-16
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus. Nat Commun, 5, 2014

4NWT

Crystal structure of the anti-human NGF Fab APE1531
Descriptor:	2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, APE1531 Ab Fab heavy chain, ...
Authors:	Verdino, P, Stanfield, R.L, Wilson, I.A.
Deposit date:	2013-12-06
Release date:	2014-10-22
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies. J.Biol.Chem., 289, 2014

4N60

Crystal structure of hemagglutinin from an H7N9 influenza virus in complex with LSTc
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, Hemagglutinin HA2, ...
Authors:	Xu, R, Wilson, I.A.
Deposit date:	2013-10-11
Release date:	2013-12-18
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (2.9032 Å)
Cite:	Preferential recognition of avian-like receptors in human influenza A H7N9 viruses. Science, 342, 2013

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