6CXL
anti-HIV-1 Fab 2G12 in complex with glycopeptide 10F5
Summary for 6CXL
Entry DOI | 10.2210/pdb6cxl/pdb |
Descriptor | anti-HIV-1 Fab 2G12 light chain, anti-HIV-1 Fab 2G12 heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose (3 entities in total) |
Functional Keywords | antibody, glycopeptide, hiv-1, glycobiology, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 97049.83 |
Authors | Stanfield, R.L.,Wilson, I.A. (deposition date: 2018-04-03, release date: 2019-02-20, Last modification date: 2020-07-29) |
Primary citation | Nguyen, D.N.,Xu, B.,Stanfield, R.L.,Bailey, J.K.,Horiya, S.,Temme, J.S.,Leon, D.R.,LaBranche, C.C.,Montefiori, D.C.,Costello, C.E.,Wilson, I.A.,Krauss, I.J. Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities. ACS Cent Sci, 5:237-249, 2019 Cited by PubMed: 30834312DOI: 10.1021/acscentsci.8b00588 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.586 Å) |
Structure validation
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