4NPY

Crystal structure of germline Fab PGT121, a putative precursor of the broadly reactive and potent HIV-1 neutralizing antibody

Summary for 4NPY

• Entry DOI: 10.2210/pdb4npy/pdb
• Related: 4FQ1 4FQC 4FQQ 4JY4 4JY5 4JY6 4NCO
• Descriptor: germline PGT121 light chain, germline PGT121 heavy chain, GLYCEROL, ... (4 entities in total)
• Functional Keywords: igg-fold, anti-hiv antibody precursor, hiv env gp120, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 96721.83

Authors

Julien, J.-P.,Diwanji, D.C.,Wilson, I.A. (deposition date: 2013-11-22, release date: 2013-12-11, Last modification date: 2023-09-20)

• Primary citation: Sok, D.,Laserson, U.,Laserson, J.,Liu, Y.,Vigneault, F.,Julien, J.P.,Briney, B.,Ramos, A.,Saye, K.F.,Le, K.,Mahan, A.,Wang, S.,Kardar, M.,Yaari, G.,Walker, L.M.,Simen, B.B.,St John, E.P.,Chan-Hui, P.Y.,Swiderek, K.,Kleinstein, S.H.,Alter, G.,Seaman, M.S.,Chakraborty, A.K.,Koller, D.,Wilson, I.A.,Church, G.M.,Burton, D.R.,Poignard, P.; The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies.; Plos Pathog., 9:e1003754-e1003754, 2013; PubMed: 24278016; DOI: 10.1371/journal.ppat.1003754

Experimental method

X-RAY DIFFRACTION (1.796 Å)