4FQC

Crystal Structure of PGT121 Fab Bound to a complex-type sialylated N-glycan

Summary for 4FQC

• Entry DOI: 10.2210/pdb4fqc/pdb
• Related: 4FQ1 4FQ2 4FQQ
• Descriptor: Fab heavy chain, Fab light chain, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: ig fold, anti hiv, antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 51026.40

Authors

Scharf, L.,Bjorkman, P.J. (deposition date: 2012-06-25, release date: 2012-11-14, Last modification date: 2021-05-19)

• Primary citation: Mouquet, H.,Scharf, L.,Euler, Z.,Liu, Y.,Eden, C.,Scheid, J.F.,Halper-Stromberg, A.,Gnanapragasam, P.N.,Spencer, D.I.,Seaman, M.S.,Schuitemaker, H.,Feizi, T.,Nussenzweig, M.C.,Bjorkman, P.J.; Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies.; Proc.Natl.Acad.Sci.USA, 109:E3268-E3277, 2012; PubMed: 23115339; DOI: 10.1073/pnas.1217207109

Experimental method

X-RAY DIFFRACTION (2.4 Å)