4NZR

Crystal structure of the antibody-binding region of Protein M (Protein M TD) in complex with anti-HIV antibody PGT135 Fab

Summary for 4NZR

• Entry DOI: 10.2210/pdb4nzr/pdb
• Related: 4JM4 4NZT 4NZU
• Descriptor: PGT135 heavy chain, PGT135 light chain, Protein M TD, ... (5 entities in total)
• Functional Keywords: leucine-rich repeat, broad antibody-binding, block antibody-antigen union, variable region, immune system-protein binding complex, immune system/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass membrane protein (Potential): P47523
• Total number of polymer chains: 3
• Total formula weight: 96245.84

Authors

Zhu, X.,Wilson, I.A. (deposition date: 2013-12-12, release date: 2014-02-19, Last modification date: 2023-09-20)

• Primary citation: Grover, R.K.,Zhu, X.,Nieusma, T.,Jones, T.,Boero, I.,MacLeod, A.S.,Mark, A.,Niessen, S.,Kim, H.J.,Kong, L.,Assad-Garcia, N.,Kwon, K.,Chesi, M.,Smider, V.V.,Salomon, D.R.,Jelinek, D.F.,Kyle, R.A.,Pyles, R.B.,Glass, J.I.,Ward, A.B.,Wilson, I.A.,Lerner, R.A.; A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.; Science, 343:656-661, 2014; PubMed: 24503852; DOI: 10.1126/science.1246135

Experimental method

X-RAY DIFFRACTION (1.65 Å)