6D0U

Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit

Summary for 6D0U

DescriptorHemagglutinin, Antibody C05 V110P/A117E mutant, heavy chain, Antibody C05, light chain, ... (4 entities in total)
Functional Keywordscomputational design, antibody, influenza, hemagglutinin, antiviral protein
Biological sourceInfluenza A virus
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Total number of polymer chains12
Total molecular weight320980.15
Authors
Wu, N.C.,Wilson, I.A. (deposition date: 2018-04-11, release date: 2019-01-16, Last modification date: 2019-02-06)
Primary citation
Sevy, A.M.,Wu, N.C.,Gilchuk, I.M.,Parrish, E.H.,Burger, S.,Yousif, D.,Nagel, M.B.M.,Schey, K.L.,Wilson, I.A.,Crowe Jr., J.E.,Meiler, J.
Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses.
Proc. Natl. Acad. Sci. U.S.A., 116:1597-1602, 2019
PubMed: 30642961 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1806004116
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.25 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2491 0.3% 2.5% 12.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report