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1G2Q
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BU of 1g2q by Molmil
CRYSTAL STRUCTURE OF ADENINE PHOSPHORIBOSYLTRANSFERASE
Descriptor: ADENINE PHOSPHORIBOSYLTRANSFERASE 1
Authors:Shi, W, Tanaka, K.S.E, Almo, S.C, Schramm, V.L.
Deposit date:2000-10-20
Release date:2001-12-05
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae.
Biochemistry, 40, 2001
1G2P
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BU of 1g2p by Molmil
CRYSTAL STRUCTURE OF ADENINE PHOSPHORIBOSYLTRANSFERASE
Descriptor: ADENINE PHOSPHORIBOSYLTRANSFERASE 1, SULFATE ION
Authors:Shi, W, Tanaka, K.S.E, Almo, S.C, Schramm, V.L.
Deposit date:2000-10-20
Release date:2001-12-05
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae.
Biochemistry, 40, 2001
4UC0
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BU of 4uc0 by Molmil
Crystal Structure Of a purine nucleoside phosphorylase (PSI-NYSGRC-029736) from Agrobacterium vitis
Descriptor: HYPOXANTHINE, Purine nucleoside phosphorylase
Authors:Cameron, S.A, Sampathkumar, P, Ramagopal, U.A, Attonito, J, Ahmed, M, Bhosle, R, Bonanno, J, Chamala, S, Chowdhury, S, Glenn, A.S, Hammonds, J, Hillerich, B, Love, J.D, Seidel, R, Stead, M, Toro, R, Wasserman, S.R, Schramm, V.L, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2014-08-13
Release date:2014-10-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure Of a purine nucleoside phosphorylase (PSI-NYSGRC-029736) from Agrobacterium vitis
To be published
1G2O
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BU of 1g2o by Molmil
CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH A TRANSITION-STATE INHIBITOR
Descriptor: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, PURINE NUCLEOSIDE PHOSPHORYLASE
Authors:Shi, W, Basso, L.A, Tyler, P.C, Furneaux, R.H, Blanchard, J.S, Almo, S.C, Schramm, V.L.
Deposit date:2000-10-20
Release date:2001-08-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
Biochemistry, 40, 2001
1K27
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BU of 1k27 by Molmil
Crystal Structure of 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with a Transition State Analogue
Descriptor: (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL, 5'-Deoxy-5'-Methylthioadenosine Phosphorylase, PHOSPHATE ION
Authors:Shi, W, Singh, V, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L.
Deposit date:2001-09-26
Release date:2003-09-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A
Biochemistry, 43, 2004
3PHC
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BU of 3phc by Molmil
Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase in complex with DADMe-ImmG
Descriptor: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Ho, M, Edwards, A.A, Almo, S.C, Schramm, V.L.
Deposit date:2010-11-03
Release date:2011-11-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase in complex with DADMe-ImmG
To be Published
3PHB
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BU of 3phb by Molmil
Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG
Descriptor: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase
Authors:Ho, M, Cassera, M.B, Murkin, A.S, Almo, S.C, Schramm, V.L.
Deposit date:2010-11-03
Release date:2011-11-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG
to be published
4ECE
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BU of 4ece by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine
Descriptor: GUANINE, Purine nucleoside phosphorylase
Authors:Haapalainen, A.M, Ho, M.C, Suarez, J.J, Almo, S.C, Schramm, V.L.
Deposit date:2012-03-26
Release date:2013-02-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
4EB8
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BU of 4eb8 by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate
Descriptor: 1,2-ETHANEDIOL, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, ...
Authors:Ho, M.C, Haapalainen, A.M, Suarez, J.J, Almo, S.C, Schramm, V.L.
Deposit date:2012-03-23
Release date:2013-02-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
4EAR
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BU of 4ear by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate
Descriptor: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase
Authors:Haapalainen, A.M, Ho, M.C, Suarez, J.J, Almo, S.C, Schramm, V.L.
Deposit date:2012-03-22
Release date:2013-02-06
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
4GKA
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BU of 4gka by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with phosphate
Descriptor: GLYCEROL, PHOSPHATE ION, Purine nucleoside phosphorylase
Authors:Haapalainen, A.M, Ho, M.C, Suarez, J.J, Almo, S.C, Schramm, V.L.
Deposit date:2012-08-10
Release date:2013-02-06
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
5TC5
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BU of 5tc5 by Molmil
Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with butylthio-DADMe-Immucillin-A and chloride
Descriptor: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, CHLORIDE ION, S-methyl-5'-thioadenosine phosphorylase
Authors:Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C.
Deposit date:2016-09-14
Release date:2017-10-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:TBA
To be published
1Y6R
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BU of 1y6r by Molmil
Crystal structure of MTA/AdoHcy nucleosidase complexed with MT-ImmA.
Descriptor: (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL, MTA/SAH nucleosidase
Authors:Lee, J.E, Singh, V, Evans, G.B, Tyler, P.C, Furneaux, R.H, Cornell, K.A, Riscoe, M.K, Schramm, V.L, Howell, P.L.
Deposit date:2004-12-06
Release date:2005-03-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
J.Biol.Chem., 280, 2005
2MAS
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BU of 2mas by Molmil
PURINE NUCLEOSIDE HYDROLASE WITH A TRANSITION STATE INHIBITOR
Descriptor: 2-(4-AMINO-PHENYL)-5-HYDROXYMETHYL-PYRROLIDINE-3,4-DIOL, CALCIUM ION, INOSINE-URIDINE NUCLEOSIDE N-RIBOHYDROLASE
Authors:Degano, M, Schramm, V.L, Sacchettini, J.C.
Deposit date:1996-10-17
Release date:1997-08-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor.
Biochemistry, 37, 1998
2I4T
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BU of 2i4t by Molmil
Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with Imm-A
Descriptor: 3,4-PYRROLIDINEDIOL,2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-2S,3S,4R,5R, PHOSPHATE ION, Trichomonas vaginalis purine nucleoside phosphorylase
Authors:Rinaldo-Matthis, A, Schramm, V.L, Almo, S.C.
Deposit date:2006-08-22
Release date:2007-06-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues.
Biochemistry, 46, 2007
2ISC
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BU of 2isc by Molmil
Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with DADMe-Imm-A
Descriptor: (3R,4R)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-(HYDROXYMETHYL)PYRROLIDIN-3-OL, PHOSPHATE ION, purine nucleoside phosphorylase
Authors:Rinaldo-Matthis, A, Almo, S.C, Schramm, V.L.
Deposit date:2006-10-17
Release date:2007-06-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues
Biochemistry, 46, 2007
1I80
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BU of 1i80 by Molmil
CRYSTAL STRUCTURE OF M. TUBERCULOSIS PNP IN COMPLEX WITH IMINORIBITOL, 9-DEAZAHYPOXANTHINE AND PHOSPHATE ION
Descriptor: 9-DEAZAHYPOXANTHINE, IMINORIBITOL, PHOSPHATE ION, ...
Authors:Shi, W, Basso, L.A, Tyler, P.C, Furneaux, R.H, Blanchard, J.S, Almo, S.C, Schramm, V.L.
Deposit date:2001-03-12
Release date:2001-08-01
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
Biochemistry, 40, 2001
1L1Q
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BU of 1l1q by Molmil
Crystal Structure of APRTase from Giardia lamblia Complexed with 9-deazaadenine
Descriptor: 9-DEAZAADENINE, Adenine phosphoribosyltransferase, SULFATE ION
Authors:Shi, W, Sarver, A.E, Wang, C.C, Tanaka, K.S, Almo, S.C, Schramm, V.L.
Deposit date:2002-02-19
Release date:2002-11-27
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Closed Site Complexes of Adenine Phosphoribosyltransferase from Giardia lamblia Reveal a Mechanism of Ribosyl Migration.
J.Biol.Chem., 277, 2002
1L1R
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BU of 1l1r by Molmil
Crystal Structure of APRTase from Giardia lamblia Complexed with 9-deazaadenine, Mg2+ and PRPP
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 9-DEAZAADENINE, Adenine phosphoribosyltransferase, ...
Authors:Shi, W, Sarver, A.E, Wang, C.C, Tanaka, K.S, Almo, S.C, Schramm, V.L.
Deposit date:2002-02-19
Release date:2002-11-27
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Closed Site Complexes of Adenine Phosphoribosyltransferase from Giardia lamblia Reveal a Mechanism of Ribosyl Migration.
J.Biol.Chem., 277, 2002
1RT9
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BU of 1rt9 by Molmil
Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and sulfate
Descriptor: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, Purine nucleoside phosphorylase, SULFATE ION
Authors:Shi, W, Lewandowicz, A, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L.
Deposit date:2003-12-10
Release date:2005-02-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural comparison of human and malarial purine nucleoside phosphorylases
To be Published
1RR6
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BU of 1rr6 by Molmil
Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and phosphate
Descriptor: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, Purine nucleoside phosphorylase
Authors:Shi, W, Lewandowicz, A, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L.
Deposit date:2003-12-08
Release date:2005-02-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.
J.Biol.Chem., 279, 2004
6DYV
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BU of 6dyv by Molmil
Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((pent-4-yn-1-ylthio)methyl)pyrrolidin-3-ol
Descriptor: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(pent-4-yn-1-yl)sulfanyl]methyl}pyrrolidin-3-ol, 1,2-ETHANEDIOL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Authors:Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.
J. Med. Chem., 62, 2019
6DZ0
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BU of 6dz0 by Molmil
Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((pent-4-yn-1-ylthio)methyl)pyrrolidin-3-ol
Descriptor: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(pent-4-yn-1-yl)sulfanyl]methyl}pyrrolidin-3-ol, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.
J. Med. Chem., 62, 2019
6DZ3
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BU of 6dz3 by Molmil
Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol
Descriptor: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl]sulfanyl}methyl)pyrrolidin-3-ol, 1,2-ETHANEDIOL, ACETIC ACID, ...
Authors:Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.
J. Med. Chem., 62, 2019
6DYW
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BU of 6dyw by Molmil
Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-benzyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol
Descriptor: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[3-(1-benzyl-1H-1,2,3-triazol-4-yl)propyl]sulfanyl}methyl)pyrrolidin-3-ol, 1,2-ETHANEDIOL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ...
Authors:Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.
J. Med. Chem., 62, 2019

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