5VJN

Crystal Structure of Adenine Phosphoribosyltransferase from Saccharomyces cerevisiae Complexed with D-2,5-Dideoxy-2,5-Imino-Altritol 1,6-Bisphosphate (D-DIAB) and Adenine

Summary for 5VJN

• Entry DOI: 10.2210/pdb5vjn/pdb
• Related: 5VJP
• Descriptor: Adenine phosphoribosyltransferase 1, [(2R,3S,4R,5R)-3,4-dihydroxypyrrolidine-2,5-diyl]bis(methylene) bis[dihydrogen (phosphate)], 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: adenine phosphoribosyltransferase, transition state analogue, d-2, 5-dideoxy-2, 5-imino-altritol-1, 6-bisphosphate, d-diab, transferase-transferase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Saccharomyces cerevisiae (Baker's yeast)
• Total number of polymer chains: 2
• Total formula weight: 42325.36

Authors

Harijan, R.K.,Ducati, R.G.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2017-04-19, release date: 2017-12-27, Last modification date: 2023-10-04)

• Primary citation: Harris, L.D.,Harijan, R.K.,Ducati, R.G.,Evans, G.B.,Hirsch, B.M.,Schramm, V.L.; Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase.; ACS Chem. Biol., 13:152-160, 2018; PubMed: 29178779; DOI: 10.1021/acschembio.7b00601

Experimental method

X-RAY DIFFRACTION (1.78 Å)