7RXW
Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor imido-diphosphate (PNP)
Summary for 7RXW
| Entry DOI | 10.2210/pdb7rxw/pdb |
| Related | 7L1A 7RXV 7RXX |
| Descriptor | S-adenosylmethionine synthase isoform type-2, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ALANINE, ... (8 entities in total) |
| Functional Keywords | sam synthetase, enzyme mechanism, inhibitor, transition state, transferase-inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 46992.54 |
| Authors | Fedorov, E.,Niland, C.N.,Schramm, V.L.,Ghosh, A. (deposition date: 2021-08-23, release date: 2021-11-10, Last modification date: 2023-10-18) |
| Primary citation | Ghosh, A.,Niland, C.N.,Cahill, S.M.,Karadkhelkar, N.M.,Schramm, V.L. Mechanism of Triphosphate Hydrolysis by Human MAT2A at 1.07 angstrom Resolution. J.Am.Chem.Soc., 143:18325-18330, 2021 Cited by PubMed: 34668717DOI: 10.1021/jacs.1c09328 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.07 Å) |
Structure validation
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