7RXW

Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor imido-diphosphate (PNP)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	S-adenosylmethionine synthase isoform type-2	polymer	417	46279.4	1	UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773)	Homo sapiens (Human)	AdoMet synthase 2,Methionine adenosyltransferase 2,MAT 2,Methionine adenosyltransferase II,MAT-II
2	B (A)	5'-DEOXY-5'-METHYLTHIOADENOSINE	non-polymer		297.3	1	Chemie (MTA)
3	C (A)	ALANINE	non-polymer		89.1	1	Chemie (ALA)
4	D (A)	IMIDODIPHOSPHORIC ACID	non-polymer		177.0	1	Chemie (2PN)
5	E (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6	F, G (A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
7	H (A)	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
8	I (A)	water	water		18.0	411	Chemie (HOH)

Sequence modifications

A: 1 - 395 (UniProt: P31153)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	46279.4
Non-Polymers*	Number of molecules	7
	Total formula weight	713.2
All*	Total formula weight	46992.5

*Water molecules are not included.