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8JIS
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BU of 8jis by Molmil
Cryo-EM structure of the GLP-1R/GCGR dual agonist peptide15-bound human GLP-1R-Gs complex
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yang, L, Zhou, Q.T, Dai, A.T, Zhao, F.H, Chang, R.L, Ying, T.L, Wu, B.L, Yang, D.H, Wang, M.W, Cong, Z.T.
Deposit date:2023-05-27
Release date:2023-11-08
Method:ELECTRON MICROSCOPY (2.46 Å)
Cite:Structural analysis of the dual agonism at GLP-1R and GCGR.
Proc.Natl.Acad.Sci.USA, 120, 2023
5V9U
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BU of 5v9u by Molmil
Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C
Descriptor: (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ...
Authors:Janes, M.R, Zhang, J, Li, L.-S, Hansen, R, Peters, U, Guo, X, Chen, Y, Babbar, A, Firdaus, S.J, Feng, J, Chen, J.H, Li, S, Brehmer, D, Darjania, L, Li, S, Long, Y.O, Thach, C, Liu, Y, Zarieh, A, Ely, T, Kucharski, J.M, Kessler, L.V, Wu, T, Wang, Y, Yao, Y, Deng, X, Zarrinkar, P, Dashyant, D, Lorenzi, M.V, Hu-Lowe, D, Patricelli, M.P, Ren, P, Liu, Y.
Deposit date:2017-03-23
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
6LMK
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BU of 6lmk by Molmil
Cryo-EM structure of the human glucagon receptor in complex with Gs
Descriptor: Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Qiao, A, Han, S, Tai, L, Sun, F, Zhao, Q, Wu, B.
Deposit date:2019-12-26
Release date:2020-04-01
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of Gsand Girecognition by the human glucagon receptor.
Science, 367, 2020
6LML
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BU of 6lml by Molmil
Cryo-EM structure of the human glucagon receptor in complex with Gi1
Descriptor: Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Qiao, A, Han, S, Li, X, Sun, F, Zhao, Q, Wu, B.
Deposit date:2019-12-26
Release date:2020-04-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of Gsand Girecognition by the human glucagon receptor.
Science, 367, 2020
8IBQ
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BU of 8ibq by Molmil
Bromodomain and Extra-terminal Domain (BET) BRD4
Descriptor: 7-[2-fluoranyl-3-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1~{H}-imidazo[4,5-b]pyridine, Bromodomain-containing protein 4
Authors:Cao, D, Zhiyan, D, Xiong, B.
Deposit date:2023-02-10
Release date:2023-10-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Discovery of 1 H -Imidazo[4,5- b ]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain.
J.Med.Chem., 66, 2023
8IDH
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BU of 8idh by Molmil
Bromodomain and Extra-terminal Domain (BET) BRD4
Descriptor: 7-[2-fluoranyl-3-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1~{H}-imidazo[4,5-b]pyridine, Bromodomain-containing protein 4
Authors:Cao, D, Zhiyan, D, Xiong, B.
Deposit date:2023-02-13
Release date:2023-10-04
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Discovery of 1 H -Imidazo[4,5- b ]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain.
J.Med.Chem., 66, 2023
7E9G
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BU of 7e9g by Molmil
Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2
Descriptor: (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one, DN13, ...
Authors:Lin, S, Han, S, Zhao, Q, Wu, B.
Deposit date:2021-03-04
Release date:2021-06-23
Last modified:2021-08-04
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of G i -bound metabotropic glutamate receptors mGlu2 and mGlu4.
Nature, 594, 2021
7E9H
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BU of 7e9h by Molmil
Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu4
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-3, ...
Authors:Lin, S, Han, S, Zhao, Q, Wu, B.
Deposit date:2021-03-04
Release date:2021-06-23
Last modified:2021-07-07
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of G i -bound metabotropic glutamate receptors mGlu2 and mGlu4.
Nature, 594, 2021
6M19
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BU of 6m19 by Molmil
Template lasso peptide C24 mutant W14F
Descriptor: lasso peptide
Authors:Liu, X.H, Liu, T, Ma, X.J, Yu, J.H, Yang, D.H, Ma, M.
Deposit date:2020-02-25
Release date:2021-03-03
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications.
Chem Sci, 12, 2021
3SBE
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BU of 3sbe by Molmil
Crystal structure of RAC1 P29S mutant
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2011-06-03
Release date:2012-07-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
5GK2
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BU of 5gk2 by Molmil
The structure of the H302A mutant of StlD
Descriptor: Ketosynthase StlD
Authors:Mori, T, Dngfeng, Y, Morita, H, Abe, I.
Deposit date:2016-07-03
Release date:2017-07-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Structural Insight into the Enzymatic Formation of Bacterial Stilbene.
Cell Chem Biol, 23, 2016
8IOD
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BU of 8iod by Molmil
Cryo-EM structure of the PG-901-bound human melanocortin receptor 5 (MC5R)-Gs complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, ...
Authors:Feng, W.B, Zhou, Q.T, Chen, X.Y, Dai, A.T, Cai, X.Q, Liu, X, Zhao, F.H, Chen, Y, Ye, C.Y, Xu, Y.N, Cong, Z.T, Li, H, Lin, S, Yang, D.H, Wang, M.W.
Deposit date:2023-03-10
Release date:2023-09-20
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.
Cell Discov, 9, 2023
8INR
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BU of 8inr by Molmil
Cryo-EM structure of the alpha-MSH-bound human melanocortin receptor 5 (MC5R)-Gs complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, ...
Authors:Feng, W.B, Zhou, Q.T, Chen, X.Y, Dai, A.T, Cai, X.Q, Liu, X, Zhao, F.H, Chen, Y, Ye, C.Y, Xu, Y.N, Cong, Z.T, Li, H, Lin, S, Yang, D.H, Wang, M.W.
Deposit date:2023-03-10
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.
Cell Discov, 9, 2023
5GK0
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BU of 5gk0 by Molmil
Crystal structure of selnomethionin-labeled ketosynthase StlD
Descriptor: Ketosynthase StlD
Authors:Mori, T, Saito, Y, Morita, H, Abe, I.
Deposit date:2016-07-03
Release date:2017-07-05
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.331 Å)
Cite:Structural Insight into the Enzymatic Formation of Bacterial Stilbene.
Cell Chem Biol, 23, 2016
5GK1
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BU of 5gk1 by Molmil
Crystal structure of the ketosynthase StlD complexed with substrate
Descriptor: 3-OXO-5-METHYLHEXANOIC ACID, Ketosynthase StlD
Authors:Mori, T, Saito, Y, Morita, H, Abe, I.
Deposit date:2016-07-03
Release date:2017-07-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural Insight into the Enzymatic Formation of Bacterial Stilbene.
Cell Chem Biol, 23, 2016
3SBD
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BU of 3sbd by Molmil
Crystal structure of RAC1 P29S mutant
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2011-06-03
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
8ITM
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BU of 8itm by Molmil
Cryo-EM structure of GIPR splice variant 2 (SV2) in complex with Gs protein
Descriptor: Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhao, F.H, Hang, K.N, Zhou, Q.T, Shao, L.J, Li, H, Li, W.Z, Lin, S, Dai, A.T, Cai, X.Q, Liu, Y.Y, Xu, Y.N, Feng, W.B, Yang, D.H, Wang, M.W.
Deposit date:2023-03-22
Release date:2023-10-18
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Molecular basis of signal transduction mediated by the human GIPR splice variants.
Proc.Natl.Acad.Sci.USA, 120, 2023
8ITL
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BU of 8itl by Molmil
Cryo-EM structure of GIPR splice variant 1 (SV1) in complex with Gs protein
Descriptor: Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhao, F.H, Hang, K.N, Zhou, Q.T, Shao, L.J, Li, H, Li, W.Z, Lin, S, Dai, A.T, Cai, X.Q, Liu, Y.Y, Xu, Y.N, Feng, W.B, Yang, D.H, Wang, M.W.
Deposit date:2023-03-22
Release date:2023-10-18
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Molecular basis of signal transduction mediated by the human GIPR splice variants.
Proc.Natl.Acad.Sci.USA, 120, 2023
5Z8F
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BU of 5z8f by Molmil
Solution structure for the unique dimeric 4:2 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex
Descriptor: 4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]-N,N-bis[4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]phenyl]aniline, G-quadruplex DNA (26-MER)
Authors:Liu, W.T, Zhong, Y.F, Liu, L.Y, Zeng, W.J, Wang, F.Y, Yang, D.Z, Mao, Z.W.
Deposit date:2018-01-31
Release date:2018-09-19
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
Nat Commun, 9, 2018
5Z80
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BU of 5z80 by Molmil
Solution structure for the 1:1 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex
Descriptor: 4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]-N,N-bis[4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]phenyl]aniline, G-quadruplex DNA (26-MER)
Authors:Liu, W.T, Zhong, Y.F, Liu, L.Y, Zeng, W.J, Wang, F.Y, Yang, D.Z, Mao, Z.W.
Deposit date:2018-01-30
Release date:2018-09-19
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
Nat Commun, 9, 2018
3TH5
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BU of 3th5 by Molmil
Crystal structure of wild-type RAC1
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2011-08-18
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
6LMS
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BU of 6lms by Molmil
Solution NMR structure cold shock domain of YB1 from Homo sapiens
Descriptor: Y-box-binding protein 1
Authors:Li, S, Zhang, J, Yang, Y.
Deposit date:2019-12-26
Release date:2020-07-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural basis of DNA binding to human YB-1 cold shock domain regulated by phosphorylation.
Nucleic Acids Res., 48, 2020
7BZ7
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BU of 7bz7 by Molmil
Template lasso peptide C24 mutant F15Y
Descriptor: lasso peptide
Authors:Liu, X.H, Liu, T, Ma, X.J, Yu, J.H, Yang, D.H, Ma, M.
Deposit date:2020-04-27
Release date:2021-04-28
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications.
Chem Sci, 12, 2021
4ZC7
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BU of 4zc7 by Molmil
Paromomycin bound to a leishmanial ribosomal A-site
Descriptor: PAROMOMYCIN, RNA duplex
Authors:Shalev, M, Rozenberg, H, Jaffe, C.L, Adir, N, Baasov, T.
Deposit date:2015-04-15
Release date:2015-08-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.041 Å)
Cite:Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.
Nucleic Acids Res., 43, 2015
8WA3
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BU of 8wa3 by Molmil
Cryo-EM structure of peptide free and Gs-coupled GIPR
Descriptor: Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ...
Authors:Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W.
Deposit date:2023-09-06
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024

223532

数据于2024-08-07公开中

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