4ZC7

Paromomycin bound to a leishmanial ribosomal A-site

Summary for 4ZC7

Entry DOI	10.2210/pdb4zc7/pdb
Descriptor	RNA duplex, PAROMOMYCIN (3 entities in total)
Functional Keywords	a-site, ribosome, paromomycin, leishmania, rna
Biological source	synthetic construct
Total number of polymer chains	4
Total formula weight	119473.02
Authors	Shalev, M.,Rozenberg, H.,Jaffe, C.L.,Adir, N.,Baasov, T. (deposition date: 2015-04-15, release date: 2015-08-26, Last modification date: 2024-01-10)
Primary citation	Shalev, M.,Rozenberg, H.,Smolkin, B.,Nasereddin, A.,Kopelyanskiy, D.,Belakhov, V.,Schrepfer, T.,Schacht, J.,Jaffe, C.L.,Adir, N.,Baasov, T. Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics. Nucleic Acids Res., 43:8601-8613, 2015 Cited by PubMed: 26264664 DOI: 10.1093/nar/gkv821 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.041 Å)

Structure validation