8ITM

Cryo-EM structure of GIPR splice variant 2 (SV2) in complex with Gs protein

Summary for 8ITM

Entry DOI	10.2210/pdb8itm/pdb
EMDB information	35707
Descriptor	Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
Functional Keywords	cryo-electron microscopy; g protein-coupled receptor; splice variant; receptor activation., structural protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	149059.27
Authors	Zhao, F.H.,Hang, K.N.,Zhou, Q.T.,Shao, L.J.,Li, H.,Li, W.Z.,Lin, S.,Dai, A.T.,Cai, X.Q.,Liu, Y.Y.,Xu, Y.N.,Feng, W.B.,Yang, D.H.,Wang, M.W. (deposition date: 2023-03-22, release date: 2023-10-18)
Primary citation	Zhao, F.,Hang, K.,Zhou, Q.,Shao, L.,Li, H.,Li, W.,Lin, S.,Dai, A.,Cai, X.,Liu, Y.,Xu, Y.,Feng, W.,Yang, D.,Wang, M.W. Molecular basis of signal transduction mediated by the human GIPR splice variants. Proc.Natl.Acad.Sci.USA, 120:e2306145120-e2306145120, 2023 Cited by PubMed: 37792509 DOI: 10.1073/pnas.2306145120 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.13 Å)

Structure validation