1KL9
| |
1KQ9
| Human methionine aminopeptidase type II in complex with L-methionine | Descriptor: | METHIONINE, Methionine aminopeptidase 2, TERTIARY-BUTYL ALCOHOL, ... | Authors: | Nonato, M.C, Widom, J, Clardy, J. | Deposit date: | 2002-01-04 | Release date: | 2003-12-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Human methionine aminopeptidase type 2 in complex with L- and D-methionine Bioorg.Med.Chem.Lett., 16, 2006
|
|
1KQ0
| Human methionine aminopeptidase type II in complex with D-methionine | Descriptor: | D-METHIONINE, Methionine aminopeptidase 2, TERTIARY-BUTYL ALCOHOL, ... | Authors: | Nonato, M.C, Widom, J, Clardy, J. | Deposit date: | 2002-01-03 | Release date: | 2003-12-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Human methionine aminopeptidase type 2 in complex with L- and D-methionine Bioorg.Med.Chem.Lett., 16, 2006
|
|
6DU9
| |
1S8I
| Crystal structure of Lys49-Phospholipase A2 from Agkistrodon contortrix laticinctus, second fatty acid free form | Descriptor: | Phospholipase A2 homolog, SULFATE ION | Authors: | Ambrosio, A.L.B, de Souza, D.H.F, Nonato, M.C, Selistre de Araujo, H.S, Ownby, C.L, Garratt, R.C. | Deposit date: | 2004-02-02 | Release date: | 2004-02-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.609 Å) | Cite: | A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change. J.Biol.Chem., 280, 2005
|
|
1S8H
| Crystal structure of Lys49-Phospholipase A2 from Agkistrodon contortrix laticinctus, first fatty acid free form | Descriptor: | Phospholipase A2 homolog, SULFATE ION | Authors: | Ambrosio, A.L.B, de Souza, D.H.F, Nonato, M.C, Selistre de Araujo, H.S, Ownby, C.L, Garratt, R.C. | Deposit date: | 2004-02-02 | Release date: | 2004-02-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change. J.Biol.Chem., 280, 2005
|
|
3MJY
| Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid | Descriptor: | 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Pinheiro, M.P, Rocha, J.R, Cheleski, J, Montanari, C.A, Nonato, M.C. | Deposit date: | 2010-04-13 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery. Eur.J.Med.Chem., 45, 2010
|
|
3MHU
| Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Nitroorotic acid | Descriptor: | 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Pinheiro, M.P, Rocha, J.R, Cheleski, J, Montanari, C.A, Nonato, M.C. | Deposit date: | 2010-04-08 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery. Eur.J.Med.Chem., 45, 2010
|
|
5L2R
| Crystal structure of fumarate hydratase from Leishmania major | Descriptor: | (2S)-2-hydroxybutanedioic acid, DI(HYDROXYETHYL)ETHER, Fumarate hydratase, ... | Authors: | Feliciano, P.R, Drennan, C.L, Nonato, M.C. | Deposit date: | 2016-08-02 | Release date: | 2016-08-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.054 Å) | Cite: | Crystal structure of an Fe-S cluster-containing fumarate hydratase enzyme from Leishmania major reveals a unique protein fold. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
7RRM
| Structure of the human TMED1 (p24gamma1) Golgi dynamics Domain | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Transmembrane emp24 domain-containing protein 1 | Authors: | Mota, D.C.A.M, Cardoso, I.A, Mori, R.M, Mendes, L.F.S, Nonato, M.C, Filho, A.J.C. | Deposit date: | 2021-08-10 | Release date: | 2021-10-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Structural and thermodynamic analyses of human TMED1 (p24 gamma 1) Golgi dynamics. Biochimie, 192, 2022
|
|
4WZH
| Dihydroorotate dehydrogenase from Leishmania Viannia braziliensis | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Reis, R.A.G, Lorenzato, E, Silva, V.C, Nonato, M.C. | Deposit date: | 2014-11-19 | Release date: | 2015-05-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Recombinant production, crystallization and crystal structure determination of dihydroorotate dehydrogenase from Leishmania (Viannia) braziliensis. Acta Crystallogr.,Sect.F, 71, 2015
|
|
4XZP
| |
6MSN
| |
6MSO
| Crystal structure of mitochondrial fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate | Descriptor: | (2S)-2-sulfanylbutanedioic acid, GLYCEROL, IRON/SULFUR CLUSTER, ... | Authors: | Feliciano, P.R, Drennan, C.L, Nonato, M.C. | Deposit date: | 2018-10-17 | Release date: | 2019-01-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.053 Å) | Cite: | Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate. ACS Chem. Biol., 14, 2019
|
|
5K9D
| Crystal structure of human dihydroorotate dehydrogenase at 1.7 A resolution | Descriptor: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Lewis, T.A, Sykes, D.B, Law, J.M, Munoz, B, Scadden, D.T, Rustiguel, J.K, Nonato, M.C, Schreiber, S.L. | Deposit date: | 2016-05-31 | Release date: | 2016-10-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett, 7, 2016
|
|
5K9Y
| Crystal structure of a thermophilic xylanase A from Bacillus subtilis 1A1 quadruple mutant Q7H/G13R/S22P/S179C | Descriptor: | Endo-1,4-beta-xylanase A | Authors: | Pinheiro, M.P, Ferreira, T.L, Silva, S.R.B, Fuzo, C.A, Silva, S.R, Lourenzoni, M.R, Vieira, D.S, Ward, R.J, Nonato, M.C. | Deposit date: | 2016-06-01 | Release date: | 2017-04-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The role of local residue environmental changes in thermostable mutants of the GH11 xylanase from Bacillus subtilis. Int. J. Biol. Macromol., 97, 2017
|
|
5K9C
| Crystal structure of human dihydroorotate dehydrogenase with ML390 | Descriptor: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Lewis, T.A, Sykes, D.B, Law, J.M, Munoz, B, Scadden, D.T, Rustiguel, J.K, Nonato, M.C, Schreiber, S.L. | Deposit date: | 2016-05-31 | Release date: | 2016-10-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett, 7, 2016
|
|
4LBQ
| Crystal structure of mouse galectin-1 | Descriptor: | GLYCEROL, Galectin-1 | Authors: | Rustiguel, J.K, Trabuco, A.C, Del Cistia Andrade, C, Stowell, S.R, Cummings, R.D, Dias-Baruffi, M, Nonato, M.C. | Deposit date: | 2013-06-20 | Release date: | 2014-07-02 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of mouse galectin-1 To be Published
|
|
5F2Q
| C-type lectin from Bothrops jararacussu | Descriptor: | C-type lectin BJcuL, CALCIUM ION, SODIUM ION | Authors: | de Padua, R.A.P, Pinheiro, M.P, Sartim, M.A, Sampaio, S.V, Nonato, M.C. | Deposit date: | 2015-12-02 | Release date: | 2016-12-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | C-type lectin from Bothrops jararacussu To Be Published
|
|
1PJA
| The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (PPT1 and PPT2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Palmitoyl-protein thioesterase 2 precursor | Authors: | Calero, G, Gupta, P, Nonato, M.C, Tandel, S, Biehl, E.R, Hofmann, S.L, Clardy, J. | Deposit date: | 2003-06-02 | Release date: | 2003-09-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2. J.Biol.Chem., 278, 2003
|
|
5CBL
| |
5D6B
| Human fumarase (wild type) | Descriptor: | Fumarate hydratase, mitochondrial | Authors: | Pereira de Padua, R.A, Nonato, M.C. | Deposit date: | 2015-08-11 | Release date: | 2016-08-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of recombinant human fumarase. Acta Crystallogr F Struct Biol Commun, 70, 2014
|
|
1S8G
| Crystal structure of Lys49-Phospholipase A2 from Agkistrodon contortrix laticinctus, fatty acid bound form | Descriptor: | GLYCEROL, LAURIC ACID, Phospholipase A2 homolog, ... | Authors: | Ambrosio, A.L.B, de Souza, D.H.F, Nonato, M.C, Selistre de Araujo, H.S, Ownby, C.L, Garratt, R.C. | Deposit date: | 2004-02-02 | Release date: | 2004-02-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change. J.Biol.Chem., 280, 2005
|
|
4EF9
| Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate | Descriptor: | Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Pinheiro, M.P, Emery, F.S, Nonato, M.C. | Deposit date: | 2012-03-29 | Release date: | 2012-12-12 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase. Curr.Pharm.Des., 19, 2013
|
|
4EF8
| Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate | Descriptor: | Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Pinheiro, M.P, Emery, F.S, Nonato, M.C. | Deposit date: | 2012-03-29 | Release date: | 2012-12-12 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase. Curr.Pharm.Des., 19, 2013
|
|