5K9C

Crystal structure of human dihydroorotate dehydrogenase with ML390

Summary for 5K9C

• Entry DOI: 10.2210/pdb5k9c/pdb
• Related: 5K9D
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, OROTIC ACID, ... (9 entities in total)
• Functional Keywords: oxidoreductase, alpha/beta barrel, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
• Total number of polymer chains: 1
• Total formula weight: 41496.72

Authors

Lewis, T.A.,Sykes, D.B.,Law, J.M.,Munoz, B.,Scadden, D.T.,Rustiguel, J.K.,Nonato, M.C.,Schreiber, S.L. (deposition date: 2016-05-31, release date: 2016-10-12, Last modification date: 2023-09-27)

• Primary citation: Lewis, T.A.,Sykes, D.B.,Law, J.M.,Munoz, B.,Rustiguel, J.K.,Nonato, M.C.,Scadden, D.T.,Schreiber, S.L.; Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.; ACS Med Chem Lett, 7:1112-1117, 2016; PubMed: 27994748; DOI: 10.1021/acsmedchemlett.6b00316

Experimental method

X-RAY DIFFRACTION (1.66 Å)