5K9C
Crystal structure of human dihydroorotate dehydrogenase with ML390
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 368 | 39943.6 | 1 | UniProt (Q02127) Pfam (PF01180) | Homo sapiens (Human) | DHOdehase,Dihydroorotate oxidase |
| 2 | B (A) | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL | non-polymer | 458.4 | 1 | Chemie (FNR) | |||
| 3 | C (A) | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 4 | D (A) | ~{N}-[3-oxidanylidene-3-[[(1~{R})-1,2,3,4-tetrahydronaphthalen-1-yl]amino]propyl]-4-(trifluoromethyloxy)benzamide | non-polymer | 406.4 | 1 | Chemie (MLJ) | |||
| 5 | E, F (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | G, H, I (A) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 7 | J, K (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 8 | L (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 9 | M (A) | water | water | 18.0 | 340 | Chemie (HOH) |
Sequence modifications
A: 30 - 396 (UniProt: Q02127)
| PDB | External Database | Details |
|---|---|---|
| Ser 29 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39943.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1553.1 | |
| All* | Total formula weight | 41496.7 |
