5K9D
Crystal structure of human dihydroorotate dehydrogenase at 1.7 A resolution
Summary for 5K9D
Entry DOI | 10.2210/pdb5k9d/pdb |
Related | 5K9C |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, OROTIC ACID, ... (9 entities in total) |
Functional Keywords | oxidoreductase, alpha/beta barrel |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion inner membrane ; Single-pass membrane protein : Q02127 |
Total number of polymer chains | 1 |
Total formula weight | 41708.59 |
Authors | Lewis, T.A.,Sykes, D.B.,Law, J.M.,Munoz, B.,Scadden, D.T.,Rustiguel, J.K.,Nonato, M.C.,Schreiber, S.L. (deposition date: 2016-05-31, release date: 2016-10-12, Last modification date: 2023-09-27) |
Primary citation | Lewis, T.A.,Sykes, D.B.,Law, J.M.,Munoz, B.,Rustiguel, J.K.,Nonato, M.C.,Scadden, D.T.,Schreiber, S.L. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett, 7:1112-1117, 2016 Cited by PubMed: 27994748DOI: 10.1021/acsmedchemlett.6b00316 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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