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5K9D

Crystal structure of human dihydroorotate dehydrogenase at 1.7 A resolution

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Dihydroorotate dehydrogenase (quinone), mitochondrialpolymer36839943.61UniProt (Q02127)
Pfam (PF01180)
Homo sapiens (Human)DHOdehase,Dihydroorotate oxidase
2B
(A)
1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOLnon-polymer458.41Chemie (FNR)
3C
(A)
OROTIC ACIDnon-polymer156.11Chemie (ORO)
4D
(A)
DODECYL NONA ETHYLENE GLYCOL ETHERnon-polymer582.81Chemie (CE9)
5E, F
(A)
SULFATE IONnon-polymer96.12Chemie (SO4)
6G, H, I
(A)
ACETATE IONnon-polymer59.03Chemie (ACT)
7J, K, L
(A)
CHLORIDE IONnon-polymer35.53Chemie (CL)
8M
(A)
GLYCEROLnon-polymer92.11Chemie (GOL)
9N
(A)
waterwater18.0395Chemie (HOH)
Sequence modifications
A: 30 - 396 (UniProt: Q02127)
PDBExternal DatabaseDetails
Ser 29-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight39943.6
Non-Polymers*Number of molecules12
Total formula weight1765.0
All*Total formula weight41708.6
*Water molecules are not included.

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PDB entries from 2026-01-14

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