6MSN

Crystal structure of cytosolic fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate

Summary for 6MSN

Descriptorfumarate hydratase, IRON/SULFUR CLUSTER, (2S)-2-sulfanylbutanedioic acid, ... (4 entities in total)
Functional Keywordsinhibitor, cytosolic, fumarate hydratase, lyase
Biological sourceLeishmania major
Total number of polymer chains2
Total molecular weight134030.52
Authors
Feliciano, P.R.,Drennan, C.L.,Nonato, M.C. (deposition date: 2018-10-17, release date: 2019-01-30, Last modification date: 2019-02-27)
Primary citation
Feliciano, P.R.,Drennan, C.L.,Nonato, M.C.
Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate.
ACS Chem. Biol., 14:266-275, 2019
PubMed: 30645090 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.8b00972
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.591 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.17010 1.2% 1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6msn
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Molmil generated image of 6msn
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