Crystal structure of cytosolic fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate

Summary for 6MSN

Descriptorfumarate hydratase, IRON/SULFUR CLUSTER, (2S)-2-sulfanylbutanedioic acid, ... (4 entities in total)
Functional Keywordsinhibitor, cytosolic, fumarate hydratase, lyase
Biological sourceLeishmania major
Total number of polymer chains2
Total molecular weight134030.52
Feliciano, P.R.,Drennan, C.L.,Nonato, M.C. (deposition date: 2018-10-17, release date: 2019-01-30, Last modification date: 2019-02-27)
Primary citation
Feliciano, P.R.,Drennan, C.L.,Nonato, M.C.
Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate.
ACS Chem. Biol., 14:266-275, 2019
PubMed: 30645090 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.8b00972
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.17010 1.2% 1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6msn
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Molmil generated image of 6msn
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Molmil generated image of 6msn
rotated about y axis by 90°