6MSN

Crystal structure of cytosolic fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004333	molecular_function	fumarate hydratase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006091	biological_process	generation of precursor metabolites and energy
A	0006099	biological_process	tricarboxylic acid cycle
A	0006106	biological_process	fumarate metabolic process
A	0006108	biological_process	malate metabolic process
A	0016829	molecular_function	lyase activity
A	0016836	molecular_function	hydro-lyase activity
A	0020015	cellular_component	glycosome
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0097014	cellular_component	ciliary plasm
B	0004333	molecular_function	fumarate hydratase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006091	biological_process	generation of precursor metabolites and energy
B	0006099	biological_process	tricarboxylic acid cycle
B	0006106	biological_process	fumarate metabolic process
B	0006108	biological_process	malate metabolic process
B	0016829	molecular_function	lyase activity
B	0016836	molecular_function	hydro-lyase activity
B	0020015	cellular_component	glycosome
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0097014	cellular_component	ciliary plasm

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SF4 A 601

Chain	Residue
A	CYS133
A	GLN134
A	GLY214
A	CYS252
A	CYS346
A	ALA348
A	LYS491
A	JYD602

---

site_id	AC2
Number of Residues	13
Details	binding site for residue JYD A 602

Chain	Residue
A	ASP135
A	ARG173
A	GLY215
A	GLY216
A	ARG421
A	THR467
A	THR468
A	ARG471
A	LYS491
A	SF4601
A	HOH829
B	ALA336
A	GLN134

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SF4 B 601

Chain	Residue
B	CYS133
B	GLN134
B	GLY214
B	CYS252
B	CYS346
B	ALA348
B	LYS491
B	JYD602

---

site_id	AC4
Number of Residues	12
Details	binding site for residue JYD B 602

Chain	Residue
B	GLN134
B	ASP135
B	ARG173
B	GLY215
B	GLY216
B	ARG421
B	THR467
B	THR468
B	ARG471
B	LYS491
B	SF4601
B	HOH818

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27528683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L2R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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