1KQ0

Human methionine aminopeptidase type II in complex with D-methionine

Summary for 1KQ0

Entry DOI	10.2210/pdb1kq0/pdb
Related	1KQ9
Descriptor	Methionine aminopeptidase 2, ZINC ION, D-METHIONINE, ... (5 entities in total)
Functional Keywords	central b-sheet and two pairs of a-helices, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	53339.70
Authors	Nonato, M.C.,Widom, J.,Clardy, J. (deposition date: 2002-01-03, release date: 2003-12-09, Last modification date: 2023-08-16)
Primary citation	Nonato, M.C.,Widom, J.,Clardy, J. Human methionine aminopeptidase type 2 in complex with L- and D-methionine Bioorg.Med.Chem.Lett., 16:2580-2583, 2006 Cited by PubMed Abstract: Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the molecular target of anti-angiogenic agents such as fumagillin and its analogues. We describe here the crystal structure of hMetAP-2 in complex with l-methionine and d-methionine at 1.9 and 2.0A resolution, respectively. The comparison of the structure of the two complexes establishes the basis of enantiomer discrimination and provides some considerations for the design of selective MetAP-2 inhibitors. PubMed: 16540317 DOI: 10.1016/j.bmcl.2006.02.047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation