4EF8
Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate
Summary for 4EF8
| Entry DOI | 10.2210/pdb4ef8/pdb |
| Related | 4EF9 |
| Descriptor | Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, N-phenylthioformamide, ... (6 entities in total) |
| Functional Keywords | leishmania major, dihydroorotate dehydrogenase, phenyl isothiocyanate, pyrd, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Leishmania major |
| Total number of polymer chains | 2 |
| Total formula weight | 78066.65 |
| Authors | Pinheiro, M.P.,Emery, F.S.,Nonato, M.C. (deposition date: 2012-03-29, release date: 2012-12-12, Last modification date: 2023-09-13) |
| Primary citation | Pinheiro, M.P.,Emery, F.S.,Nonato, M.C. Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase. Curr.Pharm.Des., 19:2615-2627, 2013 Cited by PubMed: 23116399PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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