6MSO

Crystal structure of mitochondrial fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate

Summary for 6MSO

Descriptorfumarate hydratase, IRON/SULFUR CLUSTER, GLYCEROL, ... (6 entities in total)
Functional Keywordsinhibitor, mitochondrial, fumarate hydratase, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceLeishmania major
Total number of polymer chains4
Total molecular weight263979.52
Authors
Feliciano, P.R.,Drennan, C.L.,Nonato, M.C. (deposition date: 2018-10-17, release date: 2019-01-30, Last modification date: 2019-02-27)
Primary citation
Feliciano, P.R.,Drennan, C.L.,Nonato, M.C.
Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate.
ACS Chem. Biol., 14:266-275, 2019
PubMed: 30645090 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.8b00972
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.053 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1798 0.0% 2.4% 92.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6mso
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Molmil generated image of 6mso
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Molmil generated image of 6mso
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More Biological unit images

Molmil generated image of 6mso
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Molmil generated image of 6mso
rotated about x axis by 90°
Molmil generated image of 6mso
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6mso.pdb1.gz [353.29 KB])
Coordinate files for Biological unit (6mso.pdb2.gz [345.91 KB])