6MSO
Crystal structure of mitochondrial fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | fumarate hydratase | polymer | 585 | 64713.2 | 4 | UniProt (Q4QAU9) Pfam (PF05681) Pfam (PF05683) In PDB | Leishmania major | |
2 | D, A, B, C | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 4 | Chemie (SF4) | |||
3 | A, B, C | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
4 | C, D, A, B | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 10 | Chemie (1PE) | |||
5 | D, A, B, C | (2S)-2-sulfanylbutanedioic acid | non-polymer | 150.2 | 4 | Chemie (JYD) | |||
6 | water | water | 18.0 | 867 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 549 (UniProt: Q4QAU9)
PDB | External Database | Details |
---|---|---|
Met -35 | - | initiating methionine |
Gly -34 | - | expression tag |
Ser -33 | - | expression tag |
Ser -32 | - | expression tag |
His -31 | - | expression tag |
His -30 | - | expression tag |
His -29 | - | expression tag |
His -28 | - | expression tag |
His -27 | - | expression tag |
His -26 | - | expression tag |
Ser -25 | - | expression tag |
Ser -24 | - | expression tag |
Gly -23 | - | expression tag |
Leu -22 | - | expression tag |
Val -21 | - | expression tag |
Pro -20 | - | expression tag |
Arg -19 | - | expression tag |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
His -16 | - | expression tag |
Met -15 | - | expression tag |
Ala -14 | - | expression tag |
Ser -13 | - | expression tag |
Met -12 | - | expression tag |
Thr -11 | - | expression tag |
Gly -10 | - | expression tag |
Gly -9 | - | expression tag |
Gln -8 | - | expression tag |
Gln -7 | - | expression tag |
Met -6 | - | expression tag |
Gly -5 | - | expression tag |
Arg -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Glu -1 | - | expression tag |
Phe 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 258852.8 | |
Non-Polymers* | Number of molecules | 26 |
Total formula weight | 5126.7 | |
All* | Total formula weight | 263979.5 |