8GN7
 
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8GNB
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2N28
 | | Solid-state NMR structure of Vpu | | Descriptor: | Protein Vpu | | Authors: | Zhang, H, Lin, E.C, Tian, Y, Das, B.B, Opella, S.J. | | Deposit date: | 2015-05-01 | | Release date: | 2015-09-30 | | Last modified: | 2024-05-01 | | Method: | SOLID-STATE NMR | | Cite: | Structural determination of virus protein U from HIV-1 by NMR in membrane environments.
Biochim.Biophys.Acta, 1848, 2015
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2N29
 | | Solution-state NMR structure of Vpu cytoplasmic domain | | Descriptor: | Protein Vpu | | Authors: | Zhang, H, Lin, E.C, Tian, Y, Das, B.B, Opella, S.J. | | Deposit date: | 2015-05-01 | | Release date: | 2015-09-30 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural determination of virus protein U from HIV-1 by NMR in membrane environments.
Biochim.Biophys.Acta, 1848, 2015
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3R29
 | | Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 | | Descriptor: | Nuclear receptor corepressor 2, Retinoic acid receptor RXR-alpha | | Authors: | Zhang, H, Chen, L, Chen, J, Jiang, H, Shen, X. | | Deposit date: | 2011-03-14 | | Release date: | 2011-05-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis for retinoic x receptor repression on the tetramer.
J.Biol.Chem., 286, 2011
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3R5N
 | | Crystal structure of PPARgammaLBD complexed with the agonist magnolol | | Descriptor: | 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol, Peroxisome proliferator-activated receptor gamma | | Authors: | Zhang, H, Chen, L, Chen, J, Hu, L, Jiang, H, Shen, X. | | Deposit date: | 2011-03-18 | | Release date: | 2012-02-08 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma).
Plos One, 6, 2011
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3F78
 | | Crystal structure of wild type LFA1 I domain complexed with isoflurane | | Descriptor: | 1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER, GLYCEROL, Integrin alpha-L, ... | | Authors: | Zhang, H, Wang, J.-H. | | Deposit date: | 2008-11-07 | | Release date: | 2009-06-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems.
Faseb J., 23, 2009
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3T5T
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3T7D
 | | Vall from streptomyces hygroscopicus in complex with trehalose | | Descriptor: | IMIDAZOLE, MAGNESIUM ION, Putative glycosyltransferase, ... | | Authors: | Zhang, H, Zheng, L, Qian, H, Chen, J. | | Deposit date: | 2011-07-29 | | Release date: | 2012-08-01 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural basis for the substrate specificity of ValL
To be Published
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3R2A
 | | Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 and antagonist rhein | | Descriptor: | 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, Nuclear receptor corepressor 2, Retinoic acid receptor RXR-alpha | | Authors: | Zhang, H, Chen, L, Chen, J, Jiang, H, Shen, X. | | Deposit date: | 2011-03-14 | | Release date: | 2011-05-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis for retinoic x receptor repression on the tetramer.
J.Biol.Chem., 286, 2011
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3F74
 | | Crystal structure of wild type LFA1 I domain | | Descriptor: | GLYCEROL, Integrin alpha-L, MAGNESIUM ION | | Authors: | Zhang, H, Wang, J.-H. | | Deposit date: | 2008-11-07 | | Release date: | 2009-06-23 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems.
Faseb J., 23, 2009
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3HI5
 | | Crystal structure of Fab fragment of AL-57 | | Descriptor: | Heavy chain of Fab fragment of AL-57 against alpha L I domain, light chain of Fab fragment of AL-57 against alpha L I domain | | Authors: | Zhang, H, Wang, J. | | Deposit date: | 2009-05-18 | | Release date: | 2009-09-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3R5M
 | | Crystal structure of RXRalphaLBD complexed with the agonist magnolol | | Descriptor: | 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | | Authors: | Zhang, H, Chen, L, Chen, J, Hu, L, Jiang, H, Shen, X. | | Deposit date: | 2011-03-18 | | Release date: | 2012-02-08 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma).
Plos One, 6, 2011
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3HI6
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8HWQ
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7EJ3
 | | UTP cyclohydrolase | | Descriptor: | DIPHOSPHATE, GLYCINE, GTP cyclohydrolase II, ... | | Authors: | Zhang, H, Zhang, Y, Yuchi, Z. | | Deposit date: | 2021-04-01 | | Release date: | 2022-09-21 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural and biochemical investigation of UTP cyclohydrolase
Acs Catalysis, 2021
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7DW5
 | | Crystal structure of DUX4 HD1-HD2 domain complexed with ERG sites | | Descriptor: | BROMIDE ION, DNA (5'-D(P*CP*GP*AP*CP*TP*TP*GP*AP*TP*GP*AP*GP*AP*TP*TP*AP*GP*AP*CP*TP*G)-3'), Double homeobox protein 4-like protein 2 | | Authors: | Zhang, H, Cheng, N, Li, Z, Zhang, W, Dong, X, Huang, J, Meng, G. | | Deposit date: | 2021-01-15 | | Release date: | 2021-11-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.83 Å) | | Cite: | DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.
Cancer Commun (Lond), 41, 2021
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3RAJ
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8KCB
 | | Complex of DDM1-nucleosome(H2A) complex with DDM1 bound to SHL2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase DDM1, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Zhang, H, Zhang, Y. | | Deposit date: | 2023-08-07 | | Release date: | 2024-06-26 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures.
Structure, 32, 2024
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8KCC
 | | Complex of DDM1-nucleosome(H2A.W) complex with DDM1 bound to SHL2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase DDM1, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Zhang, H, Zhang, Y. | | Deposit date: | 2023-08-07 | | Release date: | 2024-06-26 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures.
Structure, 32, 2024
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7EEV
 | | Structure of UTP cyclohydrolase | | Descriptor: | DEOXYURIDINE-5'-TRIPHOSPHATE, GTP cyclohydrolase II, ZINC ION | | Authors: | Zhang, H, Zhang, Y, Yuchi, Z. | | Deposit date: | 2021-03-19 | | Release date: | 2021-07-28 | | Last modified: | 2022-09-21 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural and biochemical investigation of UTP cyclohydrolase
Acs Catalysis, 2021
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7F1R
 | | Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi | | Descriptor: | C-C motif chemokine 5,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | | Deposit date: | 2021-06-09 | | Release date: | 2021-07-14 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Nat Commun, 12, 2021
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7F1S
 | | Cryo-EM structure of the apo chemokine receptor CCR5 in complex with Gi | | Descriptor: | C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | | Deposit date: | 2021-06-09 | | Release date: | 2021-07-14 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Nat Commun, 12, 2021
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7F1T
 | | Crystal structure of the human chemokine receptor CCR5 in complex with MIP-1a | | Descriptor: | C-C motif chemokine 3,C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION | | Authors: | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | | Deposit date: | 2021-06-09 | | Release date: | 2021-07-14 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Nat Commun, 12, 2021
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7F1Q
 | | Cryo-EM structure of the chemokine receptor CCR5 in complex with MIP-1a and Gi | | Descriptor: | C-C motif chemokine 3,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | | Deposit date: | 2021-06-09 | | Release date: | 2021-07-14 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Nat Commun, 12, 2021
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