3HI6
Crystal structure of intermediate affinity I domain of integrin LFA-1 with the Fab fragment of its antibody AL-57
Summary for 3HI6
Entry DOI | 10.2210/pdb3hi6/pdb |
Related | 3HI5 |
Descriptor | Integrin alpha-L, Heavy chain of Fab fragment of AL-57 against alpha L I domain, light chain of Fab fragment of AL-57 against alpha L I domain, ... (6 entities in total) |
Functional Keywords | integrin, i domain, fab, ligand mimetic antibody, cell adhesion, alternative splicing, calcium, disulfide bond, glycoprotein, magnesium, membrane, polymorphism, receptor, transmembrane, cell adhesion-immune system complex, cell adhesion/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P20701 |
Total number of polymer chains | 6 |
Total formula weight | 135359.17 |
Authors | |
Primary citation | Zhang, H.,Liu, J.H.,Yang, W.,Springer, T.,Shimaoka, M.,Wang, J.H. Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1. Proc.Natl.Acad.Sci.USA, 106:18345-18350, 2009 Cited by PubMed: 19805116DOI: 10.1073/pnas.0909301106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report