3HI6

Crystal structure of intermediate affinity I domain of integrin LFA-1 with the Fab fragment of its antibody AL-57

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 1

Chain	Residue
A	HOH4
A	SER139
A	SER141
A	THR206
H	ASP101
H	HOH223

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 2

Chain	Residue
B	THR206
X	ASP101
X	HOH222
B	HOH1
B	SER139
B	SER141

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 5

Chain	Residue
B	LYS197
B	HOH695
H	ASP215
H	LYS216
H	ARG217
H	HOH683

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 H 221

Chain	Residue
A	HIS275
A	PRO281
A	ALA282
A	SER283
H	LYS199
H	THR200
H	HOH261
H	HOH271
X	SER194

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 222

Chain	Residue
H	PHE27
H	THR28
H	TYR32
H	HOH297
X	LYS76

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 212

Chain	Residue
L	LYS39
L	LYS45
L	HOH259

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 X 221

Chain	Residue
X	PHE27
X	THR28
X	TYR32
X	HOH325
X	HOH674

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 Y 212

Chain	Residue
B	ASN163
B	THR164
Y	PRO59
Y	ARG61
Y	HOH273

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR191-HIS197
H	TYR201-HIS207

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	342
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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