3HI6
Crystal structure of intermediate affinity I domain of integrin LFA-1 with the Fab fragment of its antibody AL-57
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrin alpha-L | polymer | 180 | 20554.5 | 2 | UniProt (P20701) Pfam (PF00092) | Homo sapiens (human) | Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11 antigen-like family member A |
| 2 | C, E (H, X) | Heavy chain of Fab fragment of AL-57 against alpha L I domain | polymer | 220 | 23765.5 | 2 | Homo sapiens (human) | ||
| 3 | D, F (L, Y) | light chain of Fab fragment of AL-57 against alpha L I domain | polymer | 212 | 23016.4 | 2 | Homo sapiens (human) | ||
| 4 | G, H (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 5 | I, J, K, L, M... (B, H, L, X, Y) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 6 | O, P, Q, R, S... (A, B, H, L, X...) | water | water | 18.0 | 700 | Chemie (HOH) |
Sequence modifications
A, B: 128 - 307 (UniProt: P20701)
| PDB | External Database | Details |
|---|---|---|
| Cys 161 | Leu 186 | engineered mutation |
| Trp 189 | Arg 214 | variant |
| Cys 299 | Phe 324 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 134672.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 686.3 | |
| All* | Total formula weight | 135359.2 |
