7DW5
Crystal structure of DUX4 HD1-HD2 domain complexed with ERG sites
Summary for 7DW5
Entry DOI | 10.2210/pdb7dw5/pdb |
Descriptor | Double homeobox protein 4-like protein 2, DNA (5'-D(P*CP*GP*AP*CP*TP*TP*GP*AP*TP*GP*AP*GP*AP*TP*TP*AP*GP*AP*CP*TP*G)-3'), BROMIDE ION, ... (5 entities in total) |
Functional Keywords | acute lymphoblastic leukemia, dux4/igh, ergalt, clamp-like transactivation, dux4-responsive-element, alternative splicing, dna binding protein, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 60816.48 |
Authors | |
Primary citation | Zhang, H.,Cheng, N.,Li, Z.,Bai, L.,Fang, C.,Li, Y.,Zhang, W.,Dong, X.,Jiang, M.,Liang, Y.,Zhang, S.,Mi, J.,Zhu, J.,Zhang, Y.,Chen, S.J.,Zhao, Y.,Weng, X.Q.,Hu, W.,Chen, Z.,Huang, J.,Meng, G. DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia. Cancer Commun (Lond), 41:1116-1136, 2021 Cited by PubMed: 34699692DOI: 10.1002/cac2.12234 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.83 Å) |
Structure validation
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