3F78
Crystal structure of wild type LFA1 I domain complexed with isoflurane
Summary for 3F78
Entry DOI | 10.2210/pdb3f78/pdb |
Related | 3F74 |
Descriptor | Integrin alpha-L, 1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER, GLYCEROL, ... (5 entities in total) |
Functional Keywords | integrin, lfa1, i domain, inactive conformation, wild type, volatile anesthetic, isoflurane, inhibitor of integrin, cell adhesion, glycoprotein, magnesium, membrane, receptor, transmembrane |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P20701 |
Total number of polymer chains | 3 |
Total formula weight | 62980.96 |
Authors | Zhang, H.,Wang, J.-H. (deposition date: 2008-11-07, release date: 2009-06-23, Last modification date: 2023-09-06) |
Primary citation | Zhang, H.,Astrof, N.S.,Liu, J.H.,Wang, J.H.,Shimaoka, M. Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. Faseb J., 23:2735-2740, 2009 Cited by PubMed: 19332643DOI: 10.1096/fj.09-129908 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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