3F78
Crystal structure of wild type LFA1 I domain complexed with isoflurane
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ICF A 1 |
| Chain | Residue |
| A | ILE235 |
| A | TYR257 |
| A | LYS287 |
| A | GLU301 |
| A | LEU302 |
| A | LYS305 |
| A | TYR307 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 2 |
| Chain | Residue |
| A | SER283 |
| A | VAL286 |
| A | HOH330 |
| A | HOH342 |
| A | HOH364 |
| A | HIS275 |
| A | ALA282 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ICF B 2 |
| Chain | Residue |
| B | ILE235 |
| B | TYR257 |
| B | ILE259 |
| B | LYS287 |
| B | LEU298 |
| B | GLU301 |
| B | LEU302 |
| B | LYS305 |
| B | TYR307 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 3 |
| Chain | Residue |
| B | GLY246 |
| B | ASN247 |
| B | HOH323 |
| B | HOH356 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 4 |
| Chain | Residue |
| A | HOH88 |
| B | LEU205 |
| B | ASN207 |
| B | THR243 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 1 |
| Chain | Residue |
| C | SER139 |
| C | SER141 |
| C | ASP239 |
| C | HOH312 |
| C | HOH394 |
| C | HOH589 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 308 |
| Chain | Residue |
| C | HOH119 |
| C | ILE255 |
| C | LYS280 |
| C | PHE285 |
| C | HOH373 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 513 |
| Details | Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15728350","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26936951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T0P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E6U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15728350","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26936951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T0P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E6R","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26936951","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E6U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
