6LHQ
 
 | | The cryo-EM structure of coxsackievirus A16 mature virion in complex with Fab NA9D7 | | Descriptor: | SPHINGOSINE, VP1 protein, VP2 protein, ... | | Authors: | He, M.Z, Xu, L.F, Zheng, Q.B, Zhu, R, Yin, Z.C, Cheng, T, Li, S.W. | | Deposit date: | 2019-12-09 | | Release date: | 2020-02-05 | | Last modified: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
Cell Host Microbe, 27, 2020
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6LHT
 | | Localized reconstruction of coxsackievirus A16 mature virion in complex with Fab 18A7 | | Descriptor: | SPHINGOSINE, VP1 protein, heavy chain variable region of Fab 18A7, ... | | Authors: | He, M.Z, Xu, L.F, Zheng, Q.B, Zhu, R, Yin, Z.C, Cheng, T, Li, S.W. | | Deposit date: | 2019-12-10 | | Release date: | 2020-02-05 | | Last modified: | 2020-02-26 | | Method: | ELECTRON MICROSCOPY (3.67 Å) | | Cite: | Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
Cell Host Microbe, 27, 2020
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4QVC
 | | E.coli Hfq in complex with RNA Aus | | Descriptor: | RNA (5'-R(*AP*U*AP*AP*CP*UP*A)-3'), RNA-binding protein Hfq | | Authors: | Wang, L.J, Wang, W.W, Li, F.D, Wu, J.H, Gong, Q.G, Shi, Y.Y. | | Deposit date: | 2014-07-14 | | Release date: | 2015-05-27 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq
Nucleic Acids Res., 43, 2015
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5MXX
 | | Crystal structure of human SR protein kinase 1 (SRPK1) in complex with compound 1 | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, ... | | Authors: | Tallant, C, Redondo, C, Batson, J, Toop, H.D, Babaebi-Jadidib, R, Savitsky, P, Elkins, J.M, Newman, J.A, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bates, D.O, Morris, J.C, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-01-25 | | Release date: | 2017-05-24 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ACS Chem. Biol., 12, 2017
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5MY8
 | | Crystal structure of SRPK1 in complex with SPHINX31 | | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, DIMETHYL SULFOXIDE, ... | | Authors: | Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-01-25 | | Release date: | 2017-05-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ACS Chem. Biol., 12, 2017
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8QFT
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5MYV
 | | Crystal structure of SRPK2 in complex with compound 1 | | Descriptor: | 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, DIMETHYL SULFOXIDE, SRSF protein kinase 2,SRSF protein kinase 2, ... | | Authors: | Chaikuad, A, Pike, A.C.W, Savitsky, P, von Delft, F, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-01-29 | | Release date: | 2017-05-10 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ACS Chem. Biol., 12, 2017
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8H69
 | | Cryo-EM structure of influenza RNA polymerase | | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-R(*UP*AP*AP*AP*CP*UP*CP*CP*UP*GP*CP*UP*UP*UP*UP*GP*CP*U)-3'), ... | | Authors: | Li, H, Wu, Y, Liang, H, Liu, Y. | | Deposit date: | 2022-10-16 | | Release date: | 2023-06-28 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles.
Nat.Struct.Mol.Biol., 30, 2023
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4RSE
 | | Crystal structure of RPE65 in complex with MB-001 and palmitate | | Descriptor: | (1R)-3-amino-1-{3-[(2,6,6-trimethylcyclohex-1-en-1-yl)methoxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ... | | Authors: | Kiser, P.D, Shi, W, Palczewski, K. | | Deposit date: | 2014-11-07 | | Release date: | 2015-04-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.
Nat.Chem.Biol., 11, 2015
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5ZFZ
 | | Crystal structure of human DUX4 homeodomains bound to A12T DNA mutant | | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*AP*TP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*AP*TP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4-like protein 4 | | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | | Deposit date: | 2018-03-07 | | Release date: | 2018-10-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for multiple gene regulation by human DUX4.
Biochem. Biophys. Res. Commun., 505, 2018
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4RSC
 | | Crystal structure of RPE65 in complex with emixustat and palmitate | | Descriptor: | (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, FE (II) ION, PALMITIC ACID, ... | | Authors: | Kiser, P.D, Shi, W, Palczewski, K. | | Deposit date: | 2014-11-07 | | Release date: | 2015-04-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.
Nat.Chem.Biol., 11, 2015
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5ZFW
 | | Crystal structure of human DUX4 homeodomains bound to A11G DNA mutant | | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*GP*AP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*TP*CP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4-like protein 4 | | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | | Deposit date: | 2018-03-07 | | Release date: | 2018-10-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.103 Å) | | Cite: | Structural basis for multiple gene regulation by human DUX4.
Biochem. Biophys. Res. Commun., 505, 2018
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5ZFY
 | | Crystal structure of human DUX4 homeodomains bound to A12C DNA mutant | | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*AP*CP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*GP*TP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4-like protein 4 | | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | | Deposit date: | 2018-03-07 | | Release date: | 2018-10-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for multiple gene regulation by human DUX4.
Biochem. Biophys. Res. Commun., 505, 2018
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4QVD
 | | E.coli Hfq in complex with RNA Ads | | Descriptor: | RNA (5'-R(*AP*AP*CP*UP*AP*AP*A)-3'), RNA-binding protein Hfq | | Authors: | Wang, L.J, Wang, W.W, Li, F.D, Wu, J.H, Gong, Q.G, Shi, Y.Y. | | Deposit date: | 2014-07-14 | | Release date: | 2015-05-27 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.972 Å) | | Cite: | Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq
Nucleic Acids Res., 43, 2015
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5Z6Z
 | | Crystal structure of human DUX4 homeodomains bound to DNA | | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*AP*AP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*TP*TP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4 | | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | | Deposit date: | 2018-01-26 | | Release date: | 2018-10-31 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | Structural basis for multiple gene regulation by human DUX4.
Biochem. Biophys. Res. Commun., 505, 2018
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7ZJ7
 | | X-31 Hemagglutinin Precursor HA0 at pH 4.8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin,Fibritin, ... | | Authors: | Garcia-Moro, E, Rosenthal, P.B. | | Deposit date: | 2022-04-08 | | Release date: | 2022-08-17 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.95 Å) | | Cite: | Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8WTW
 | | Cryo-EM structure of noradrenaline transporter in complex with a x-MrlA analogue | | Descriptor: | CHLORIDE ION, MrlA, SODIUM ION, ... | | Authors: | Zhao, Y, Hu, T, Yu, Z. | | Deposit date: | 2023-10-19 | | Release date: | 2024-08-07 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
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7ZJ8
 | | X-31 Hemagglutinin Precursor HA0 at pH 7.5 after reneutralization | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin,Fibritin, ... | | Authors: | Garcia-Moro, E, Rosenthal, P.B. | | Deposit date: | 2022-04-08 | | Release date: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8WTU
 | | Cryo-EM structure of noradrenaline transporter in apo state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent noradrenaline transporter | | Authors: | Zhao, Y, Hu, T, Yu, Z. | | Deposit date: | 2023-10-19 | | Release date: | 2024-08-07 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
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8WTX
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6NPK
 | | Structure of the TM domain | | Descriptor: | Solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | | Authors: | Feng, L, Liao, M.F, Orlando, B, Zhang, J.R. | | Deposit date: | 2019-01-17 | | Release date: | 2019-07-31 | | Last modified: | 2019-08-28 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure and mechanism of the cation-chloride cotransporter NKCC1.
Nature, 572, 2019
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8WTY
 | | Cryo-EM structure of noradrenaline transporter in complex with ziprasidone | | Descriptor: | 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloranyl-1,3-dihydroindol-2-one, Sodium-dependent noradrenaline transporter | | Authors: | Zhao, Y, Hu, T, Yu, Z. | | Deposit date: | 2023-10-19 | | Release date: | 2024-08-07 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
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8WTV
 | | Cryo-EM structure of noradrenaline transporter in complex with noradrenaline | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Noradrenaline, ... | | Authors: | Zhao, Y, Hu, T, Yu, Z. | | Deposit date: | 2023-10-19 | | Release date: | 2024-08-07 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
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8VK2
 | | X-ray crystal structure of human IgE 4C8 Fab | | Descriptor: | IgE 4C8 heavy chain, IgE 4C8 light chain | | Authors: | Khatri, K, Ball, A, Smith, S.A, Champan, M.D, Pomes, A, Chruszcz, M. | | Deposit date: | 2024-01-08 | | Release date: | 2024-06-19 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.508 Å) | | Cite: | Structural analysis of human IgE monoclonal antibody epitopes on dust mite allergen Der p 2.
J.Allergy Clin.Immunol., 154, 2024
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8VK1
 | | X-ray crystal structure of human IgE 4C8 Fab complex with Der p 2.0103 | | Descriptor: | Der p 2 variant 3, IgE 4C8 heavy chain, IgE 4C8 light chain | | Authors: | Khatri, K, Ball, A, Smith, S.A, Champan, M.D, Pomes, A, Chruszcz, M. | | Deposit date: | 2024-01-08 | | Release date: | 2024-06-19 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Structural analysis of human IgE monoclonal antibody epitopes on dust mite allergen Der p 2.
J.Allergy Clin.Immunol., 154, 2024
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