5MY8

Crystal structure of SRPK1 in complex with SPHINX31

Summary for 5MY8

Entry DOI	10.2210/pdb5my8/pdb
Descriptor	SRSF protein kinase 1,SRSF protein kinase 1, CITRIC ACID, GLYCEROL, ... (7 entities in total)
Functional Keywords	transferase, splicing kinase, inhibitor, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (Human) More
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cytoplasm: Q96SB4
Total number of polymer chains	1
Total formula weight	45711.33
Authors	Chaikuad, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2017-01-25, release date: 2017-05-10)
Primary citation	Batson, J.,Toop, H.D.,Redondo, C.,Babaei-Jadidi, R.,Chaikuad, A.,Wearmouth, S.F.,Gibbons, B.,Allen, C.,Tallant, C.,Zhang, J.,Du, C.,Hancox, J.C.,Hawtrey, T.,Da Rocha, J.,Griffith, R.,Knapp, S.,Bates, D.O.,Morris, J.C. Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem. Biol., 12:825-832, 2017 Cited by PubMed: 28135068 DOI: 10.1021/acschembio.6b01048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation