8VK1

X-ray crystal structure of human IgE 4C8 Fab complex with Der p 2.0103

Summary for 8VK1

• Entry DOI: 10.2210/pdb8vk1/pdb
• Descriptor: IgE 4C8 light chain, Der p 2 variant 3, IgE 4C8 heavy chain, ... (4 entities in total)
• Functional Keywords: dust mite allergy, house dust mite, der p 2-ige complex, human ige against der p 2, antibody-allergen complex, antibody-allergen interaction, allergen-immune system complex, allergen/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 122156.94

Authors

Khatri, K.,Ball, A.,Smith, S.A.,Champan, M.D.,Pomes, A.,Chruszcz, M. (deposition date: 2024-01-08, release date: 2024-06-19, Last modification date: 2024-11-13)

Primary citation

Ball, A.,Khatri, K.,Glesner, J.,Vailes, L.D.,Wunschmann, S.,Gabel, S.A.,Mueller, G.A.,Zhang, J.,Peebles Jr., R.S.,Chapman, M.D.,Smith, S.A.,Chruszcz, M.,Pomes, A.
Structural analysis of human IgE monoclonal antibody epitopes on dust mite allergen Der p 2.
J.Allergy Clin.Immunol., 154:447-457, 2024

PubMed Abstract: Human IgE (hIgE) mAbs against major mite allergen Der p 2 developed using human hybridoma technology were used for IgE epitope mapping and analysis of epitopes associated with the hIgE repertoire.

PubMed: 38697404
DOI: 10.1016/j.jaci.2024.04.017

Experimental method

X-RAY DIFFRACTION (3.05 Å)