8H69

Cryo-EM structure of influenza RNA polymerase

Summary for 8H69

• Entry DOI: 10.2210/pdb8h69/pdb
• EMDB information: 34497
• Descriptor: RNA (5'-R(*UP*AP*AP*AP*CP*UP*CP*CP*UP*GP*CP*UP*UP*UP*UP*GP*CP*U)-3'), RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*AP*GP*UP*UP*UP*U)-3'), Polymerase acidic protein, ... (5 entities in total)
• Functional Keywords: rna polymerase, viral protein
• Biological source: Influenza A virus (A/goose/Guangdong/1/1996(H5N1)); More
• Total number of polymer chains: 5
• Total formula weight: 266874.75

Authors

Li, H.,Wu, Y.,Liang, H.,Liu, Y. (deposition date: 2022-10-16, release date: 2023-06-28, Last modification date: 2023-11-15)

• Primary citation: Li, H.,Wu, Y.,Li, M.,Guo, L.,Gao, Y.,Wang, Q.,Zhang, J.,Lai, Z.,Zhang, X.,Zhu, L.,Lan, P.,Rao, Z.,Liu, Y.,Liang, H.; An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles.; Nat.Struct.Mol.Biol., 30:1183-1192, 2023; PubMed: 37488357; DOI: 10.1038/s41594-023-01043-2

Experimental method

ELECTRON MICROSCOPY (3.7 Å)