8H69

Cryo-EM structure of influenza RNA polymerase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (3)	RNA (5'-R(*UP*AP*AP*AP*CP*UP*CP*CP*UP*GP*CP*UP*UP*UP*UP*GP*CP*U)-3')	polymer	18	5608.3	1		Influenza A virus (A/goose/Guangdong/1/1996(H5N1))
2	B (5)	RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*AP*GP*UP*UP*UP*U)-3')	polymer	19	6150.7	1		Influenza A virus (A/goose/Guangdong/1/1996(H5N1))
3	C (A)	Polymerase acidic protein	polymer	716	82669.5	1	UniProt (Q91R78) Pfam (PF00603) UniProt (by SIFTS) (Q9Q0U9)	Influenza A virus (A/goose/Guangdong/1/1996(H5N1))
4	D (B)	RNA-directed RNA polymerase catalytic subunit	polymer	757	86492.2	1	UniProt (Q91HA4) Pfam (PF00602) UniProt (by SIFTS) (Q9Q0V0)	Influenza A virus (A/goose/Guangdong/1/1996(H5N1))
5	E (C)	Polymerase basic protein 2	polymer	759	85954.0	1	UniProt (Q6E3M8) Pfam (PF20947) Pfam (PF20948) Pfam (PF20949) Pfam (PF20950) Pfam (PF00604) Pfam (PF20951) Pfam (PF20952) UniProt (by SIFTS) (Q9Q0V1)	Influenza A virus (A/goose/Guangdong/1/1996(H5N1))	RNA-directed RNA polymerase subunit P3

Sequence modifications

A: 1 - 716 (UniProt: Q91R78)

PDB	External Database	Details
Val 100	Ile 100	conflict
Thr 567	Ala 567	conflict

B: 1 - 757 (UniProt: Q91HA4)

PDB	External Database	Details
Glu 148	Gly 148	conflict

C: 1 - 759 (UniProt: Q6E3M8)

PDB	External Database	Details
Thr 106	Lys 106	conflict
Glu 358	Asp 358	conflict
Arg 641	Gly 641	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	266874.7
All*	Total formula weight	266874.7

*Water molecules are not included.