Crystal structure of RPE65 in complex with MB-001 and palmitate

Summary for 4RSE

Related3FSN 4F2Z 4RSC
DescriptorRetinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ... (5 entities in total)
Functional Keywords7-bladed beta propeller, monotopic membrane protein, non-heme iron enzyme, smooth endoplasmic reticulum, retinoid isomerase, isomerase
Biological sourceBos taurus (bovine,cow,domestic cattle,domestic cow)
Cellular locationCytoplasm Q28175
Total number of polymer chains2
Total molecular weight123101.49
Kiser, P.D.,Shi, W.,Palczewski, K. (deposition date: 2014-11-07, release date: 2015-04-15, Last modification date: 2015-06-03)
Primary citation
Kiser, P.D.,Zhang, J.,Badiee, M.,Li, Q.,Shi, W.,Sui, X.,Golczak, M.,Tochtrop, G.P.,Palczewski, K.
Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.
Nat.Chem.Biol., 11:409-415, 2015
PubMed: 25894083 (PDB entries with the same primary citation)
DOI: 10.1038/nchembio.1799
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.235101.7%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload