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8T5C
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BU of 8t5c by Molmil
Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8.11G Heavy Chain, 8.11G Light Chain, ...
Authors:Gorman, J, Kwong, P.D.
Deposit date:2023-06-13
Release date:2024-01-03
Last modified:2024-01-24
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability.
Nat Commun, 15, 2024
8T1G
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BU of 8t1g by Molmil
The crystal structure of hemagglutinin form a h7n9 influenza virus (a/shanghai/1/2013) in complex with antibody 1E11
Descriptor: 1E11 Fab Heavy chain, 1E11 Fab Light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhou, T, Kwong, P.D.
Deposit date:2023-06-02
Release date:2024-05-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The crystal structure of hemagglutinin form a h7n9 influenza virus (a/shanghai/1/2013) in complex with antibody 1E11
To Be Published
7TXD
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BU of 7txd by Molmil
Cryo-EM structure of BG505 SOSIP HIV-1 Env trimer in complex with CD4 receptor (D1D2) and broadly neutralizing darpin bnD.9
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Broadly neutralizing darpin bnd.9, ...
Authors:Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L.
Deposit date:2022-02-08
Release date:2023-04-12
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.
Nat.Struct.Mol.Biol., 30, 2023
6OT1
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BU of 6ot1 by Molmil
Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122
Descriptor: 0PV-b.01 heavy, 0PV-b.01 light, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gorman, J, Kwong, P.D.
Deposit date:2019-05-02
Release date:2019-08-07
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
6P7H
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BU of 6p7h by Molmil
Vaccine-elicited NHP FP-targeting neutralizing antibody DF2F-b.04 in complex with HIV fusion peptide (residue 512-519)
Descriptor: Antibody DF2F-b.04 heavy chain, Antibody DF2F-b.04 light chain, HIV fusion peptide residues (512-519)
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-05
Release date:2020-06-10
Method:X-RAY DIFFRACTION (1.782 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6P60
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BU of 6p60 by Molmil
Vaccine-elicited NHP FP-targeting neutralizing antibody A12V163-a.02 in complex with HIV fusion peptide (residue 512-519)
Descriptor: Antibody A12V163-a.02 heavy chain, Antibody A12V163-a.02 light chain, HIV fusion peptide residue 512-519
Authors:Xu, K, Liu, K, Kwong, P.D.
Deposit date:2019-05-31
Release date:2020-06-03
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:Vaccine-elicited NHP FP-targeting neutralizing antibody A12V163-a.02 in complex with HIV fusion peptide (residue 512-519)
To Be Published
6P8D
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BU of 6p8d by Molmil
Vaccine-elicited murine FP-targeting antibody vFP6.01 in complex with HIV fusion peptide (residue 512-519)
Descriptor: Antibody VFP6.01 heavy chain, Antibody VFP6.01 light chain, HIV fusion peptide residue 512-519
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-07
Release date:2020-06-10
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6PEC
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BU of 6pec by Molmil
Vaccine-elicited NHP FP-targeting antibody DF2F-e.01 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV-1 fusion peptide residue 512-519, antibody heavy chain, antibody light chain
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-20
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.746 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6PEF
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BU of 6pef by Molmil
Vaccine-elicited NHP FP-targeting antibody DF2F-a.01 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV fusion peptide residue 512-519, antibody DF2F-a.01 heavy chain, antibody DF2F-a.01 light chain
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-20
Release date:2020-06-24
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6PDS
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BU of 6pds by Molmil
Vaccine-elicited NHP FP-targeting antibody 0PV-a.04 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV-1 fusion peptide residue 512-519, SULFATE ION, antibody 0PV-a.04 heavy chain, ...
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-19
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6PDR
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BU of 6pdr by Molmil
Vaccine-elicited murine FP-targeting antibody vFP25.18 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV fusion peptide residue 512-519, antibody vFP25.18 heavy chain, antibody vFP25.18 light chain
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-19
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.555 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6PDU
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BU of 6pdu by Molmil
Vaccine-elicited NHP FP-targeting antibody 13N024-a.01 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV-1 fusion peptide residue 512-519, antibody 13N024-a.01, heavy chain, ...
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-19
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.953 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6Q0S
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BU of 6q0s by Molmil
Crystal Structure of RSV strain B18537 Prefusion-stabilized glycoprotein F Variant DS-Cav1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, SULFATE ION
Authors:Joyce, M.G, Bao, A, Kwong, P.D.
Deposit date:2019-08-02
Release date:2020-01-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B.
Pathog Immun, 4, 2019
6OSY
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BU of 6osy by Molmil
Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122
Descriptor: 0PV-a.01 Heavy, 0PV-a.01 Light, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gorman, J, Kwong, P.D.
Deposit date:2019-05-02
Release date:2019-07-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
3HI1
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BU of 3hi1 by Molmil
Structure of HIV-1 gp120 (core with V3) in Complex with CD4-Binding-Site Antibody F105
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, F105 Heavy Chain, F105 Light Chain, ...
Authors:Kwon, Y.D, Chen, L, Zhou, T, Wu, X, O'Dell, S, Cavacini, L, Hessell, A.J, Pancera, M, Tang, M, Xu, L, Yang, Z, Zhang, M.-Y, Arthos, J, Burton, D.R, Dimitrov, D, Nabel, G.J, Posner, M, Sodroski, J, Wyatt, R, Mascola, J.R, Kwong, P.D.
Deposit date:2009-05-18
Release date:2009-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Science, 326, 2009
6N8D
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BU of 6n8d by Molmil
Crystal structure of GII.4 2002 norovirus P domain in complex with neutralizing human antibody A1431
Descriptor: A1431 Fab heavy chain, A1431 Fab light chain, Major capsid protein
Authors:Changela, A, Verardi, R, Kwong, P.D.
Deposit date:2018-11-29
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Sera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination.
Immunity, 50, 2019
6N81
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BU of 6n81 by Molmil
Crystal structure of GII.4 2002 norovirus P domain in complex with cross-reactive human antibody A1227
Descriptor: A1227 Fab heavy chain, A1227 Fab light chain, Major capsid protein
Authors:Changela, A, Verardi, R, Kwong, P.D.
Deposit date:2018-11-28
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.579 Å)
Cite:Sera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination.
Immunity, 50, 2019
5EWI
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BU of 5ewi by Molmil
Crystal Structure of the Human Fab VRC38.01, an HIV-1 V1V2-Directed Neutralizing Antibody Isolated from Donor N90
Descriptor: VRC38.01 Heavy Chain, VRC38.01 Light Chain
Authors:Gorman, J, Kwong, P.D.
Deposit date:2015-11-20
Release date:2016-11-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5996 Å)
Cite:Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.
Immunity, 46, 2017
4DVW
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BU of 4dvw by Molmil
Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with MAE-II-167
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-(4-chloro-3-fluorophenyl)-N'-[(3aS,6aS)-hexahydrocyclopenta[c]pyrrol-3a(1H)-ylmethyl]ethanediamide, ...
Authors:Kwon, Y.D, Kwong, P.D.
Deposit date:2012-02-23
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site.
Plos One, 9, 2014
4DKV
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BU of 4dkv by Molmil
Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with NBD-10007
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 gp120 core, ...
Authors:Kwon, Y.D, Debnath, A.K, Kwong, P.D.
Deposit date:2012-02-04
Release date:2013-03-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1847 Å)
Cite:Binding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study.
Antimicrob. Agents Chemother., 58, 2014
4DQO
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BU of 4dqo by Molmil
Crystal Structure of PG16 Fab in Complex with V1V2 Region from HIV-1 strain ZM109
Descriptor: 1FD6-V1V2 scaffold ZM109 HIV-1 strain, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PG16 Fab Heavy Chain, ...
Authors:Pancera, M, McLellan, J.S, Kwong, P.D.
Deposit date:2012-02-16
Release date:2013-03-06
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.438 Å)
Cite:Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.
Nat.Struct.Mol.Biol., 20, 2013
4DVR
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BU of 4dvr by Molmil
Crystal structure of YU2 gp120 core in complex with Fab 48d and NBD-557
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, Fab 48d Heavy chain, ...
Authors:Kwon, Y.D, Kwong, P.D.
Deposit date:2012-02-23
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site.
Plos One, 9, 2014
4DVS
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BU of 4dvs by Molmil
Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with NBD-557
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-(4-bromophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)ethanediamide, ...
Authors:Kwon, Y.D, Kwong, P.D.
Deposit date:2012-02-23
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site.
Plos One, 9, 2014
4DVT
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BU of 4dvt by Molmil
Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-II-37
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-(4-chloro-3-fluorophenyl)-N'-[(1S)-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl]ethanediamide, ...
Authors:Kwon, Y.D, Kwong, P.D.
Deposit date:2012-02-23
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site.
Plos One, 9, 2014
4DVX
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BU of 4dvx by Molmil
Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with MAE-II-188
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-(4-chloro-3-fluorophenyl)-N'-{[(3R)-1-cyclopropylpyrrolidin-3-yl]methyl}ethanediamide, ...
Authors:Kwon, Y.D, Kwong, P.D.
Deposit date:2012-02-23
Release date:2013-02-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site.
Plos One, 9, 2014

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