7TXD

Cryo-EM structure of BG505 SOSIP HIV-1 Env trimer in complex with CD4 receptor (D1D2) and broadly neutralizing darpin bnD.9

Summary for 7TXD

Entry DOI	10.2210/pdb7txd/pdb
EMDB information	26157
Descriptor	Envelope glycoprotein gp120, Envelope glycoprotein gp41, T-cell surface glycoprotein CD4, ... (9 entities in total)
Functional Keywords	hiv, env, broadly neutralizing, darpin, cd4, viral protein
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	12
Total formula weight	358164.75
Authors	Cerutti, G.,Gorman, J.,Kwong, P.D.,Shapiro, L. (deposition date: 2022-02-08, release date: 2023-04-12, Last modification date: 2023-09-27)
Primary citation	Glogl, M.,Friedrich, N.,Cerutti, G.,Lemmin, T.,Kwon, Y.D.,Gorman, J.,Maliqi, L.,Mittl, P.R.E.,Hesselman, M.C.,Schmidt, D.,Weber, J.,Foulkes, C.,Dingens, A.S.,Bylund, T.,Olia, A.S.,Verardi, R.,Reinberg, T.,Baumann, N.S.,Rusert, P.,Dreier, B.,Shapiro, L.,Kwong, P.D.,Pluckthun, A.,Trkola, A. Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization. Nat.Struct.Mol.Biol., 30:1323-1336, 2023 Cited by PubMed: 37605043 DOI: 10.1038/s41594-023-01062-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.87 Å)

Structure validation