8T5C

Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5

Summary for 8T5C

• Entry DOI: 10.2210/pdb8t5c/pdb
• EMDB information: 41048
• Descriptor: Glycoprotein G1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
• Functional Keywords: vaccine, gpc, gp1, gp2, viral protein-immune system complex, viral protein/immune system
• Biological source: Lassa virus Josiah; More
• Total number of polymer chains: 11
• Total formula weight: 216540.92

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2023-06-13, release date: 2024-01-03, Last modification date: 2024-01-24)

• Primary citation: Gorman, J.,Cheung, C.S.,Duan, Z.,Ou, L.,Wang, M.,Chen, X.,Cheng, C.,Biju, A.,Sun, Y.,Wang, P.,Yang, Y.,Zhang, B.,Boyington, J.C.,Bylund, T.,Charaf, S.,Chen, S.J.,Du, H.,Henry, A.R.,Liu, T.,Sarfo, E.K.,Schramm, C.A.,Shen, C.H.,Stephens, T.,Teng, I.T.,Todd, J.P.,Tsybovsky, Y.,Verardi, R.,Wang, D.,Wang, S.,Wang, Z.,Zheng, C.Y.,Zhou, T.,Douek, D.C.,Mascola, J.R.,Ho, D.D.,Ho, M.,Kwong, P.D.; Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability.; Nat Commun, 15:285-285, 2024; PubMed: 38177144; DOI: 10.1038/s41467-023-44534-y

Experimental method

ELECTRON MICROSCOPY (4.7 Å)