8T5C
Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A, C | Glycoprotein G1 | polymer | 202 | 22884.9 | 3 | UniProt (P08669) Pfam (PF00798) In PDB | Lassa virus Josiah | GP1 |
2 | b, a, c | Glycoprotein G2 | polymer | 194 | 22143.2 | 3 | UniProt (P08669) Pfam (PF00798) In PDB | Lassa virus Josiah | GP2 |
3 | D | D5 nanobody | polymer | 120 | 13228.5 | 1 | Camelus bactrianus | ||
4 | H, E | 8.11G Heavy Chain | polymer | 120 | 13257.6 | 2 | Homo sapiens | ||
5 | L, I | 8.11G Light Chain | polymer | 109 | 12101.5 | 2 | Homo sapiens | ||
6 | F | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
7 | X, G, Q, U | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
8 | J, K, V | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 383.3 | 3 | In PDB GlyTouCan (G90333CG) | |||
9 | M, R, W | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | In PDB GlyTouCan (G09724ZC) | |||
10 | N, S | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
11 | O | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G42227JK) | |||
12 | P | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose | branched | 504.4 | 1 | In PDB GlyTouCan (G00619DD) | |||
13 | T | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G34442SS) | |||
14 | B, b, A, a, C... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 23 | Chemie (NAG) |
Sequence modifications
B, A, C: 59 - 257 (UniProt: P08669)
b, a, c: 260 - 418 (UniProt: P08669)
PDB | External Database | Details |
---|---|---|
Gly 206 | Arg 207 | conflict |
Cys 207 | - | insertion |
Arg 258 | - | expression tag |
Arg 259 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Cys 326 | Leu 326 | conflict |
Pro 329 | Glu 329 | conflict |
Gly 419 | - | expression tag |
Gly 420 | - | expression tag |
Gly 421 | - | expression tag |
Tyr 422 | - | expression tag |
Ile 423 | - | expression tag |
Pro 424 | - | expression tag |
Glu 425 | - | expression tag |
Ala 426 | - | expression tag |
Pro 427 | - | expression tag |
Arg 428 | - | expression tag |
Asp 429 | - | expression tag |
Gly 430 | - | expression tag |
Gln 431 | - | expression tag |
Ala 432 | - | expression tag |
Tyr 433 | - | expression tag |
Val 434 | - | expression tag |
Arg 435 | - | expression tag |
Lys 436 | - | expression tag |
Asp 437 | - | expression tag |
Gly 438 | - | expression tag |
Glu 439 | - | expression tag |
Trp 440 | - | expression tag |
Val 441 | - | expression tag |
Leu 442 | - | expression tag |
Leu 443 | - | expression tag |
Ser 444 | - | expression tag |
Thr 445 | - | expression tag |
Phe 446 | - | expression tag |
Leu 447 | - | expression tag |
Gly 448 | - | expression tag |
Gly 449 | - | expression tag |
Leu 450 | - | expression tag |
Val 451 | - | expression tag |
Pro 452 | - | expression tag |
Arg 453 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 11 |
Total formula weight | 199030.9 | |
Branched | Number of molecules | 16 |
Total formula weight | 12422.2 | |
Non-Polymers* | Number of molecules | 23 |
Total formula weight | 5087.8 | |
All* | Total formula weight | 216540.9 |