4DQO

Crystal Structure of PG16 Fab in Complex with V1V2 Region from HIV-1 strain ZM109

Summary for 4DQO

• Entry DOI: 10.2210/pdb4dqo/pdb
• Related: 3MME 3MUG 3U2S
• Descriptor: PG16 Fab Heavy Chain, PG16 Fab Light Chain, 1FD6-V1V2 scaffold ZM109 HIV-1 strain, ... (6 entities in total)
• Functional Keywords: immunoglobulin, immune recognition, immune system, glycan, hiv-1, v1v2, envelope glycoprotein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 66160.91

Authors

Pancera, M.,McLellan, J.S.,Kwong, P.D. (deposition date: 2012-02-16, release date: 2013-03-06, Last modification date: 2023-12-06)

• Primary citation: Pancera, M.,Shahzad-Ul-Hussan, S.,Doria-Rose, N.A.,McLellan, J.S.,Bailer, R.T.,Dai, K.,Loesgen, S.,Louder, M.K.,Staupe, R.P.,Yang, Y.,Zhang, B.,Parks, R.,Eudailey, J.,Lloyd, K.E.,Blinn, J.,Alam, S.M.,Haynes, B.F.,Amin, M.N.,Wang, L.X.,Burton, D.R.,Koff, W.C.,Nabel, G.J.,Mascola, J.R.,Bewley, C.A.,Kwong, P.D.; Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.; Nat.Struct.Mol.Biol., 20:804-813, 2013; PubMed: 23708607; DOI: 10.1038/nsmb.2600

Experimental method

X-RAY DIFFRACTION (2.438 Å)