4DVT

Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-II-37

Summary for 4DVT

Entry DOI	10.2210/pdb4dvt/pdb
Related	4DVR 4DVS 4DVU 4DVV 4DVW 4DVX
Descriptor	clade A/E 93TH057 HIV-1 gp120 core, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-(4-chloro-3-fluorophenyl)-N'-[(1S)-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl]ethanediamide, ... (5 entities in total)
Functional Keywords	hiv-1 gp120, small molecule inhibitor, cd4 binding site, as-ii-37, viral protein-transcription inhibitor complex, viral protein/transcription inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	84387.52
Authors	Kwon, Y.D.,Kwong, P.D. (deposition date: 2012-02-23, release date: 2013-02-27, Last modification date: 2023-09-13)
Primary citation	Kwon, Y.D.,Lalonde, J.M.,Yang, Y.,Elban, M.A.,Sugawara, A.,Courter, J.R.,Jones, D.M.,Smith, A.B.,Debnath, A.K.,Kwong, P.D. Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. Plos One, 9:e85940-e85940, 2014 Cited by PubMed: 24489681 DOI: 10.1371/journal.pone.0085940 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation