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4Y5O
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BU of 4y5o by Molmil
CCM2 HHD in complex with MEKK3 NPB1
Descriptor: Malcavernin, Mitogen-activated protein kinase kinase kinase 3
Authors:Fisher, O.S, Boggon, T.J.
Deposit date:2015-02-11
Release date:2015-07-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.
Nat Commun, 6, 2015
8JZS
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BU of 8jzs by Molmil
Outward-facing SLC15A4 dimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, lysosomal transporter
Authors:Zhang, S.S, Chen, X.D, Xie, M.
Deposit date:2023-07-06
Release date:2023-09-27
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.
Nat Commun, 14, 2023
8JZU
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BU of 8jzu by Molmil
SLC15A4_TASL complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, TLR adapter,Green fluorescent protein, TSLAA-EGPF tag fusion protein
Authors:Zhang, S.S, Chen, X.D, Xie, M.
Deposit date:2023-07-06
Release date:2023-09-27
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.
Nat Commun, 14, 2023
8JZR
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BU of 8jzr by Molmil
Outward_facing SLC15A4 monomer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, lysosomal transporter,ALFA tag
Authors:Zhang, S.S, Chen, X.D, Xie, M.
Deposit date:2023-07-06
Release date:2023-09-27
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.
Nat Commun, 14, 2023
3HFA
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BU of 3hfa by Molmil
Crystal Structure of Mycobacterium Tuberculosis Proteasome open-gate mutant
Descriptor: DIMETHYLFORMAMIDE, Proteasome (Alpha subunit) PrcA, Proteasome (Beta subunit) PrcB
Authors:Li, D, Li, H.
Deposit date:2009-05-11
Release date:2009-09-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.504 Å)
Cite:Inhibitors selective for mycobacterial versus human proteasomes.
Nature, 461, 2009
3H6I
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BU of 3h6i by Molmil
Crystal Structure of Mycobacterium Tuberculosis Proteasome Modified by inhibitor GL1
Descriptor: DIMETHYLFORMAMIDE, Proteasome (Alpha subunit) PrcA, Proteasome (Beta subunit) PrcB
Authors:Li, D, Li, H, Lin, G.
Deposit date:2009-04-23
Release date:2009-09-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Inhibitors selective for mycobacterial versus human proteasomes.
Nature, 461, 2009
3HF9
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BU of 3hf9 by Molmil
Crystal Structure of Mycobacterium Tuberculosis Proteasome open-gate mutant modified by inhibitor GL1
Descriptor: Proteasome (Alpha subunit) PrcA, Proteasome (Beta subunit) PrcB
Authors:Li, D, Li, H.
Deposit date:2009-05-11
Release date:2009-09-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.878 Å)
Cite:Inhibitors selective for mycobacterial versus human proteasomes.
Nature, 461, 2009
3H6F
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BU of 3h6f by Molmil
Crystal Structure of Mycobacterium Tuberculosis Proteasome Modified by inhibitor HT1171
Descriptor: DIMETHYLFORMAMIDE, Proteasome (Alpha subunit) PrcA, Proteasome (Beta subunit) PrcB
Authors:Li, D, Li, H, Lin, G.
Deposit date:2009-04-23
Release date:2009-09-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Inhibitors selective for mycobacterial versus human proteasomes.
Nature, 461, 2009
2LWF
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BU of 2lwf by Molmil
Structure of N-terminal domain of a plant Grx
Descriptor: Monothiol glutaredoxin-S16, chloroplastic
Authors:Feng, Y.
Deposit date:2012-07-28
Release date:2013-05-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts.
Proc.Natl.Acad.Sci.USA, 110, 2013
4C13
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BU of 4c13 by Molmil
x-ray crystal structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys
Descriptor: CHLORIDE ION, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Ruane, K.M, Roper, D.I, Fulop, V, Barreteau, H, Boniface, A, Dementin, S, Blanot, D, Mengin-Lecreulx, D, Gobec, S, Dessen, A, Dowson, C.G, Lloyd, A.J.
Deposit date:2013-08-09
Release date:2013-10-02
Last modified:2021-03-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy.
Nat.Chem.Biol., 2021
5JUN
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BU of 5jun by Molmil
PB2 bound to an azaindole inhibitor
Descriptor: (3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-3-(1-methylcyclobutyl)propanoic acid, Polymerase basic protein 2
Authors:Jacobs, M.D.
Deposit date:2016-05-10
Release date:2017-05-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Discovery of Novel, Orally Bioavailable beta-Amino Acid Azaindole Inhibitors of Influenza PB2.
ACS Med Chem Lett, 8, 2017
5JUR
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BU of 5jur by Molmil
PB2 bound to an azaindole inhibitor
Descriptor: (3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-4,4-dimethyl-pentanoic acid, Polymerase basic protein 2
Authors:Jacobs, M.D.
Deposit date:2016-05-10
Release date:2017-03-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Discovery of Novel, Orally Bioavailable beta-Amino Acid Azaindole Inhibitors of Influenza PB2.
ACS Med Chem Lett, 8, 2017
2I4T
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BU of 2i4t by Molmil
Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with Imm-A
Descriptor: 3,4-PYRROLIDINEDIOL,2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-2S,3S,4R,5R, PHOSPHATE ION, Trichomonas vaginalis purine nucleoside phosphorylase
Authors:Rinaldo-Matthis, A, Schramm, V.L, Almo, S.C.
Deposit date:2006-08-22
Release date:2007-06-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues.
Biochemistry, 46, 2007
4IKP
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BU of 4ikp by Molmil
Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin
Descriptor: (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, Histone-arginine methyltransferase CARM1, ...
Authors:Dong, A, Dombrovski, L, He, H, Ibanez, G, Wernimont, A, Zheng, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2012-12-27
Release date:2013-02-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
Elife, 8, 2019
4I51
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BU of 4i51 by Molmil
Methyltransferase domain of HUMAN EUCHROMATIC HISTONE METHYLTRANSFERASE 1, mutant Y1211A
Descriptor: GLYCEROL, H3K9 NE-ALLYL PEPTIDE, Histone-lysine N-methyltransferase EHMT1, ...
Authors:Dong, A, Zeng, H, Walker, J.R, Islam, K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Lou, M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2012-11-28
Release date:2012-12-19
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
Proc.Natl.Acad.Sci.USA, 110, 2013
5EIB
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BU of 5eib by Molmil
Crystal structure of CPAP PN2-3 C-terminal loop-helix in complex with DARPin-tubulin
Descriptor: Designed ankyrin repeat protein, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Li, H, Zheng, X.
Deposit date:2015-10-29
Release date:2016-10-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
Nat Commun, 7, 2016
5CI6
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BU of 5ci6 by Molmil
Crystal structure of Arabidopsis thaliana MPK6
Descriptor: Mitogen-activated protein kinase 6
Authors:Qin, X, Li, P, Chen, Z, Ren, D.
Deposit date:2015-07-11
Release date:2016-05-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Analysis of crystal structure of Arabidopsis MPK6 and generation of its mutants with higher activity
Sci Rep, 6, 2016
5HGU
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BU of 5hgu by Molmil
Crystal structure of human transcription factor TEAD2 in complex with palmitate
Descriptor: PALMITIC ACID, Transcriptional enhancer factor TEF-4
Authors:Luo, X, Xiao, H.
Deposit date:2016-01-08
Release date:2016-02-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.046 Å)
Cite:Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway.
Nat.Chem.Biol., 12, 2016
7XXL
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BU of 7xxl by Molmil
RBD in complex with Fab14
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab14 heavy chain, Fab14 light chain, ...
Authors:Lin, J.Q, Tan, Y.J.E, Wu, B, Lescar, J.
Deposit date:2022-05-30
Release date:2022-09-14
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
Nat Commun, 13, 2022
5YGI
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BU of 5ygi by Molmil
Crystal structure of human FPPS in complex with an inhibitor THZ93
Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Li, X.
Deposit date:2017-09-23
Release date:2018-09-26
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.177 Å)
Cite:The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell, 175, 2018
4Z0V
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BU of 4z0v by Molmil
The structure of human PDE12 residues 161-609
Descriptor: 2',5'-phosphodiesterase 12, GLYCEROL, MAGNESIUM ION
Authors:Nolte, R.T, Wisely, B, Wang, L, Wood, E.R.
Deposit date:2015-03-26
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015
4Z2B
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BU of 4z2b by Molmil
The structure of human PDE12 residues 161-609 in complex with GSK3036342A
Descriptor: 1,2-ETHANEDIOL, 2',5'-phosphodiesterase 12, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Nolte, R.T, Wisely, B, Wang, L, Wood, E.R.
Deposit date:2015-03-29
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015
3LT3
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BU of 3lt3 by Molmil
Crystal structure of Rv3671c from M. tuberculosis H37Rv, Ser343Ala mutant, inactive form
Descriptor: POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE
Authors:Biswas, T, Small, J, Vandal, O, Ehrt, S, Tsodikov, O.V.
Deposit date:2010-02-14
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.
Structure, 18, 2010
3J3W
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BU of 3j3w by Molmil
Atomic model of the immature 50S subunit from Bacillus subtilis (state II-a)
Descriptor: 50S ribosomal protein L1, 50S ribosomal protein L11, 50S ribosomal protein L13, ...
Authors:Li, N, Guo, Q, Zhang, Y, Yuan, Y, Ma, C, Lei, J, Gao, N.
Deposit date:2013-04-28
Release date:2013-06-12
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (10.7 Å)
Cite:Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit
Nucleic Acids Res., 41, 2013
3J3V
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BU of 3j3v by Molmil
Atomic model of the immature 50S subunit from Bacillus subtilis (state I-a)
Descriptor: 50S ribosomal protein L1, 50S ribosomal protein L11, 50S ribosomal protein L13, ...
Authors:Li, N, Guo, Q, Zhang, Y, Yuan, Y, Ma, C, Lei, J, Gao, N.
Deposit date:2013-04-28
Release date:2013-06-12
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (13.3 Å)
Cite:Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit
Nucleic Acids Res., 41, 2013

221716

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